Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D?
Ann Rheumat Dis 69(6):1155-7 (2010)
profile H Amital, profile Z Szekanecz, profile G Szücs, profile K Dankó, profile E Nagy, profile T Csépány, profile E Kiss, profile J Rovensky, profile A Tuchynova, profile D Kozakova, profile A Doria, profile N Corocher, profile N Agmon-Levin, profile V Barak, profile H Orbach, profile G Zandman-Goddard and profile Y Shoenfeld
Correspondence to Professor Yehuda Shoenfeld, Department of Medicine 'B' and Centre for Autoimmune Diseases, Sheba Medical Centre, (Affiliated to Tel-Aviv University) Tel-Hashomer 52621, Israel; shoenfel at post.tau.ac.il.
BACKGROUND: Low serum vitamin D concentrations have been reported in several autoimmune disorders.
OBJECTIVE: To assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE).
METHODS: 378 patients from several European and Israeli cohorts were pooled and their disease activity was measured by two different methods: 278 patients had SLE disease activity-2000 (SLEDAI-2K) scores and 100 patients had European Consensus Lupus Activity Measurement (ECLAM) scores. In order to combine the two systems the scores were converted into standardised values (z-scores), enabling univariate summary statistics for the two variables (SLEDAI-2K and ECLAM). The commercial kit, LIAISON 25-OH vitamin D assay (310900-Diasorin) was used to measure serum concentration of 25-OH vitamin D in 378 patients with SLE. RESULTS: /st> A significant negative correlation was demonstrated between the serum concentration of vitamin D and the standardised values (z-scores) of disease activity scores as measured by the SLEDAI-2K and ECLAM scales (Pearson's correlation coefficient r=-0.12, p=0.018).
CONCLUSIONS: In a cohort of patients with SLE originating from Israel and Europe vitamin D serum concentrations were found to be inversely related to disease activity. DOI: 10.1136/ard.2009.120329 PMID: 20439290
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