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Lupus is both prevented and treated by Vitamin D – review Dec 2017

Role of vitamin D deficiency in systemic lupus erythematosus incidence and aggravation

Autoimmunity Highlights, November 2018, 9:1
Tohid Hassanalilou, Leila Khalili, Saeid Ghavamzadeh, Ali ShokriLaleh Payahoo, Yaser Khaje Bishak (Iran)

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Vitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiation, is the main source of vitamin D. Since lupus patients are usually photosensitive, the risk of developing vitamin D deficiency in is high in this population.
Although evidences showed the connotation between systemic lupus erythematosus (SLE) and vitamin D through which SLE can lead to lower vitamin D levels, it is also important to consider the possibility that vitamin D deficiency may have a causative role in SLE etiology. This paper analyzes existing data from various studies to highlight the role of vitamin D deficiency in SLE occurrence and aggravation and the probable efficacy of vitamin D supplementation on SLE patients. We searched “Science Direct” and “Pub Med” using “Vitamin D” and “SLE” for finding the studies focusing on the association between vitamin D deficiency and SLE incidence and consequences. Evidences show that vitamin D plays an important role in the pathogenesis and progression of SLE and vitamin D supplementation seems to ameliorate inflammatory and hemostatic markers; so, can improve clinical subsequent.

Fig. 1 The two-sided relation between vitamin D and SLE showing that low levels of vitamin D resulted from SLE and SLE complications come from vitamin D defciency


Fig. 2 The benefcial efects of vitamin D in prevention and/or control of SLE


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ID Name Comment Uploaded Size Downloads
9035 Lupus F2.jpg admin 26 Dec, 2017 54.77 Kb 2134
9034 Lupus F1.jpg admin 26 Dec, 2017 62.30 Kb 2238
9033 Lupus Dec 2017.pdf admin 26 Dec, 2017 1.02 Mb 759