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Kidney problems reduces Vitamin K. which causes cardiovascular problems – Aug 2018

The Vitamin K Metabolome in Chronic Kidney Disease.

Nutrients. 2018 Aug 12;10(8). pii: E1076. doi: 10.3390/nu10081076.
Turner ME1, Adams MA2, Holden RM3,4.


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The purpose of this review is to summarize the research to date on the impact of chronic kidney disease (CKD) on the vitamin K metabolome. Vitamin K-dependent proteins contribute to cardiovascular disease (CVD) prevention via the prevention of ectopic mineralization. Sub-clinical vitamin K deficiency is common in CKD patients, and evidence suggests that it may contribute to the CVD burden in this population. Research from animal models suggests that CKD alters tissue measures of the two predominant forms of vitamin K: KI and MK-4. The expression and/or activity of enzymes that regulate the recycling of vitamin K and the carboxylation of vitamin K-dependent proteins also appear to be altered in CKD. Evidence suggests that statins, a common pharmaceutical prescribed to CKD patients to prevent cardiovascular events, may impact the metabolism of vitamin K and therefore contribute to its relative inefficiency at preventing CVD in this population as kidney disease progresses. Human research on the tissue vitamin K metabolome in CKD patients is lacking.

Created by admin. Last Modification: Tuesday August 21, 2018 18:08:01 GMT-0000 by admin. (Version 2)

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10394 Vit K and Kidney disease.pdf admin 21 Aug, 2018 18:04 213.47 Kb 572