Kidney problems reduces Vitamin K. which causes cardiovascular problems – Aug 2018

The Vitamin K Metabolome in Chronic Kidney Disease.

Nutrients. 2018 Aug 12;10(8). pii: E1076. doi: 10.3390/nu10081076.
Turner ME1, Adams MA2, Holden RM3,4.

1 Department of Biomedical and Molecular Science, Queen's University, Kingston, ON K7L 3V6, Canada. mandy.turner@queensu.ca.
2 Department of Biomedical and Molecular Science, Queen's University, Kingston, ON K7L 3V6, Canada. adams@queensu.ca.
3 Department of Biomedical and Molecular Science, Queen's University, Kingston, ON K7L 3V6, Canada. rachel.holden@kingstonhsc.ca.
4 Department of Medicine, Queen's University, Kingston, ON K7L 3V6, Canada. rachel.holden@kingstonhsc.ca.

VitaminDWiki

Chronic kidney disease associated with higher levels of vitamin K1 – July 2012
- Seems to claim the opposite of the study on this page

Kidney category starts with

Overview Kidney and vitamin D contains the following summary

FACT: The Kidneys are not the primary way to activate vitamin D; the tissues are
FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
FACT: There are many ongoing intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
  Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
Nanoemulstion vitamin D (inside cheek, topically) gets activated Vitamin D to the cells without the need for healthy kidney, liver, or intestine
Calcitriol - which bypasses the need for the kidney to activate vitamin D
  Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
    Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
Category Kidney and Vitamin D contains 225 items

Download the PDF from VitaminDWiki

The purpose of this review is to summarize the research to date on the impact of chronic kidney disease (CKD) on the vitamin K metabolome. Vitamin K-dependent proteins contribute to cardiovascular disease (CVD) prevention via the prevention of ectopic mineralization. Sub-clinical vitamin K deficiency is common in CKD patients, and evidence suggests that it may contribute to the CVD burden in this population. Research from animal models suggests that CKD alters tissue measures of the two predominant forms of vitamin K: KI and MK-4. The expression and/or activity of enzymes that regulate the recycling of vitamin K and the carboxylation of vitamin K-dependent proteins also appear to be altered in CKD. Evidence suggests that statins, a common pharmaceutical prescribed to CKD patients to prevent cardiovascular events, may impact the metabolism of vitamin K and therefore contribute to its relative inefficiency at preventing CVD in this population as kidney disease progresses. Human research on the tissue vitamin K metabolome in CKD patients is lacking.