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Hay Fever treated by Vitamin D (50,000 IU weekly) – RCT July 2019

Therapeutic effect of vitamin D supplementation on allergic rhinitis.

Eur Arch Otorhinolaryngol. 2019 Jul 22. doi: 10.1007/s00405-019-05546-x.
Bakhshaee M1, Sharifian M1, Esmatinia F1, Rasoulian B2, Mohebbi M3.


Reduction even though Vitamin D levels were only raised to 24 ng
Far more reduction expected if most of the vitamin D levels were raised to 40 ng
Higher level can be achieved by one or more of the following:
  1) Loading dose – example: 400,000 IU over a week
  2) More frequent dose – example: every 4 days instead of 7 days)
  3) Longer trial – example: 20 weeks instead of 8 weeks
      Note: Vitamin D levels often take 12 to 20 weeks to plateau

See also VitaminDWiki

 Download the PDF from Sci-Hub via VitaminDWiki

Grassroots Health chart of the data__

In this study, we aimed to determine whether short-term (2 months) vitamin D supplementation could improve the allergic symptoms in AR patients.

A randomized double-blind placebo-controlled clinical trial was performed on allergic rhinitis patients with vitamin D deficiency from Nov. 2017-2018. 80 cases with allergic rhinitis and vitamin D deficiency were divided into two groups and vitamin D plus routine antihistamine medication (cetirizine) was prescribed for the study group, whereas the control group received cetirizine plus placebo. The clinical symptoms questionnaire was completed at baseline and after 4 and 8 weeks of treatment initiation. Vitamin D levels were re-measured at the end of the 8-week treatment course.

In total, 80 patients with allergic rhinitis and vitamin D deficiency were enrolled. Among them, 35 cases and 33 controls visited the clinic after 8 weeks; the mean age in the aforementioned groups was 29.68 years and 29.13 years demonstrating no meaningful difference (P > 0.05). At study initiation, the mean vitamin D level was 14 ng/ml and 14.67 ng/ml in the study and control groups, respectively, indicating no significant difference (P = 0.189). The mean serum vitamin D level at 8 weeks of treatment in the study group (24.08 ng/ml) indicated a statistically meaningful difference with the mean vitamin D level at baseline (P < 0.001). Comparison of the mean scores of symptoms severity showed no significant difference between the two groups at study initiation and 4 weeks later (P = 0.073), whereas a significant difference was obtained between baseline and 8 weeks of treatment initiation (P = 0.007).

Based on the findings of the present study, it can be concluded that vitamin D supplementation along with antihistamines can result in relative symptoms improvement in AR patients with vitamin D deficiency.

Created by admin. Last Modification: Friday July 9, 2021 17:22:16 GMT-0000 by admin. (Version 15)

Attached files

ID Name Comment Uploaded Size Downloads
12419 Allergy 50,000 IU weekly.jpg admin 02 Aug, 2019 71.28 Kb 1264
12385 Hay fever.jpg admin 24 Jul, 2019 45.89 Kb 1080
12384 Hay Fever RCT Sci-Hub.pdf admin 24 Jul, 2019 422.92 Kb 614