Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour
European Journal of Cancer, Vol 103, Nov 2018, Pages 98-107, https://doi.org/10.1016/j.ejca.2018.07.130
TsuyoshiHamadaa1LiLiuabc1JonathanA.Nowakd1KosukeMimaeYinCaobfghKimmieNgeTyler S.TwomblyaMingyangSongbfgSeungyounJungiRuoxuDoueYoheiMasugiaKeisukeKosumiaYanShiajAnnacarolinada SilvaaMancangGuakWanwanLiaNaNaKeumblKanaWubmn…ShujiOginoadnr2
VitaminDWiki was unable to quickly find out what peritumoural lymphocytic reaction is
- Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018
- Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis Dec 2016
- Chemotheraphy not work as well with low Vitamin D (colon cancer this time) – Aug 2018
- Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017
PDF is available free at Sci-Hub 10.1016/j.ejca.2018.07.130
- The survival association of vitamin D is stronger in cancer with fewer lymphocytes.
- Vitamin D and peritumoural lymphocytes interact to modify cancer progression.
- Vitamin D may exert anti-tumour immune-enhancing effects.
- Peritumoural lymphocytic reaction may be a biomarker for benefits from vitamin D
- Our data support immunomodulatory lifestyle interventions for cancer patients.
High-level plasma 25-hydroxyvitamin D [25(OH)D] has been associated with lower colorectal cancer incidence and mortality. Considering evidence indicating immunomodulatory effects of vitamin D, we hypothesised that survival benefits from high systemic vitamin D level might be stronger for colorectal carcinoma with lower immune response to tumour.
Using 869 colon and rectal cancer cases within the Nurses' Health Study and Health Professionals Follow-up Study, we assessed the prognostic association of postdiagnosis 25(OH)D score [derived from diet and lifestyle variables to predict plasma 25(OH)D level] in strata of levels of histopathologic lymphocytic reaction. The Cox proportional hazards regression model was adjusted for potential confounders, including microsatellite instability, CpG island methylator phenotype, LINE-1 methylation, PTGS2 (cyclooxygenase-2) expression and KRAS, BRAF and PIK3CA mutations.
The association of postdiagnosis 25(OH)D score with colorectal cancer-specific mortality differed by levels of peritumoural lymphocytic reaction (pinteraction = 0.001). Multivariable-adjusted mortality hazard ratios for a quintile-unit increase of 25(OH)D score were 0.69 [95% confidence interval (CI), 0.54–0.89] in cases with negative/low peritumoural lymphocytic reaction, 1.08 (95% CI, 0.93–1.26) in cases with intermediate peritumoural reaction and 1.25 (95% CI, 0.75–2.09) in cases with high peritumoural reaction. The survival association of the 25(OH)D score did not significantly differ by Crohn's-like lymphoid reaction, intratumoural periglandular reaction or tumour-infiltrating lymphocytes.
The association between the 25(OH)D score and colorectal cancer survival is stronger for carcinomas with lower peritumoural lymphocytic reaction. Our results suggesting interactive effects of vitamin D and immune response may contribute to personalised dietary and lifestyle intervention strategies.
peritumoural lymphocytic reaction