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800 IU vitamin D for infant and 2000 IU for mother is good, not great – RCT Dec 2013

Comment by VitaminDWiki

  • 2000 IU before and after pregnancy in addition to 800 IU for infant
  • Other studies have found that 2,000 IU to mother provides virtually no vitamin D via breast milk
  • Note that vitamin D levels dropped in infants – 800 IU probably not enough
  • Many countries now considering 1,000 to 1,600 IU for infants

Vitamin D During Pregnancy and Infancy and Infant Serum 25-Hydroxyvitamin D Concentration

Pediactrics online December 16, 2013, (doi: 10.1542/peds.2013-2602)
Cameron C. Grant, MBChB, PhDa,
Alistair W. Stewart, BScb,
Robert Scragg, MBBS, PhDb,
Tania Milnea,
Judy Rowdena,
Alec Ekeroma, MBBSc,
Clare Wall, PhDd,
Edwin A. Mitchell, MBBS, DSca,
Sue Crengle, MBChB, PhDe,
Adrian Trenholme, MB, BChirf,
Julian Crane, MBBSg, and
Carlos A. Camargo Jr, MD, DrPHh
A Paediatrics: Child and Youth Health,
B Epidemiology and Biostatistics,
C Obstetrics and Gynaecology,
D Nutrition, and
E Te Kupenga Hauora Maori, University of Auckland, Auckland, New Zealand;
F Women and Children's Health, Middlemore Hospital, Auckland, New Zealand;
G Medicine, University of Otago, Wellington, New Zealand; and
H Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

OBJECTIVE: To determine the vitamin D dose necessary to achieve serum 25-hydroxyvitamin D (25(OH)D) concentration ≥20 ng/mL during infancy.

METHODS: A randomized, double-blind, placebo-controlled trial in New Zealand. Pregnant mothers, from 27 weeks’ gestation to birth, and then their infants, from birth to age 6 months, were randomly assigned to 1 of 3 mother/infant groups: placebo/placebo, vitamin D3 1000/400 IU, or vitamin D3 2000/800 IU. Serum 25(OH)D and calcium concentrations were measured at enrollment, 36 weeks’ gestation, in cord blood, and in infants at 2, 4, and 6 months of age.

RESULTS: Two-hundred-and-sixty pregnant women were randomized. At enrollment, the proportions with serum 25(OH)D ≥20 ng/mL for placebo, lower-dose, and higher-dose groups were 54%, 64%, and 55%, respectively. The proportion with 25(OH)D ≥20 ng/mL was larger in both intervention groups at 36 weeks’ gestation (50%, 91%, 89%, P < .001). In comparison with placebo, the proportion of infants with 25(OH)D ≥20 ng/mL was larger in both intervention groups to age 4 months: cord blood (22%, 72%, 71%, P < .001), 2 months (50%, 82%, 92%, P < .001), and 4 months (66%, 87%, 87%, P = .004), but only in the higher-dose group at age 6 months (74%, 82%, 89%, P = .07; higher dose versus placebo P = .03, lower dose versus placebo P = .21).

CONCLUSIONS: Daily vitamin D supplementation during pregnancy and then infancy with 1000/400 IU or 2000/800 IU increases the proportion of infants with 25(OH)D ≥20 ng/mL, with the higher dose sustaining this increase for longer.
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PDF is attached at the bottom of this page

See also VitaminDWiki

Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRandomized Controlled Trial
3. Gestational Diabetes 3 times Randomized Controlled Trial
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times Randomized Controlled Trial
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times Randomized Controlled Trial
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
Randomized Controlled Trial
10. Childhood Wheezing 1.3 times Randomized Controlled Trial
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRandomized Controlled Trial
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times Randomized Controlled Trial
16. Childhood Respiratory Tract visits 2.5 times Randomized Controlled Trial

See also web

Attached files

ID Name Comment Uploaded Size Downloads
3478 2000 IU.jpg admin 03 Jan, 2014 03:20 53.65 Kb 1318
3477 2000 and 800 IU.pdf PDF - 2014 admin 03 Jan, 2014 03:20 1.85 Mb 567
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