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50,000 IU of vitamin D for 8 weeks of pregnancy raised most above 30 nanograms - RCT Jan 2017

Can weekly vitamin d dosing adequately treat vitamin d deficiency in pregnancy?

American Journal of Obstetrics and Gynecology, Volume 216, Issue 1, Supplement, January 2017, Pages S380-S381
Brianne Bimson, Lois Brustman, Zainab Al Ibraheemi, Kimberly Herrera, Barak Rosenn
Mount Sinai West Hospital, new york, NY
This is 1 of 875 posters to be presented at 37th Annual Meeting of the Society for Maternal Fetal Medicine - Jan 2017
Behind a $36 paywall - which I paid
Publisher provided no abstract

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  • Both arms of the RCT got 400 IU daily
  • Vitamin D levels were measured 8 to 12 weeks after the start of the trial
  • No indication why they stopped the Vitamin D supplementation at 8 weeks
    As would be expected the vitamin D levels dropped a lot after the supplementation stopped
  • Average level achieved at 8 weeks was 48 nanograms
  • Some got above 70 nanograms
    This is probably due to taking the vitamin D sample within a few days of the last 50,000 IU dose
  • 2 had their vitamin D levels drop
  • 84% became vitamin D sufficient at 8 weeks (> 30 ng)
  • No indication that they recorded the outcome differences between the RCT ARMS

Have thought about this study for a day and have not been able to come up with a single reason for the study


See also VitaminDWiki

Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

Attached files

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7577 Pergnancy 50,000 IU 8 weeks.jpg admin 28 Dec, 2016 02:42 31.27 Kb 479
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