Monthly Fluctuations in 25-hydroxy-vitamin D Levels in Day and Rotating Night Shift Hospital Workers
J Endocrinol Invest. 2020 Apr 27. doi: 10.1007/s40618-020-01265-x.
S Rizza 1, A Pietroiusti 2, A Farcomeni 3, G G Mina 2, M Caruso 2, M Virgilio 2, A Magrini 2, M Federici 4, L Coppeta 2
- Shiftwork diseases are often due to lack of vitamin D
- Shift workers 2X more likely to get COVID-19 (low Vitamin D) - Dec 2020
- Reduced Vitamin D status in rotating shift workers in the summer and fall – April 2020
- Shift workers have low vitamin D, poorer sleep, and are more depressed – March 2019
- Employers should give night shift workers free vitamin D – GMB Union June 2019
- Miscarriage 32 percent more likely if work night shift (probably low Vitamin D) – April 2019
- Shiftworkers and Indoor Workers have lower Vitamin D levels – review of 10 studies Sept 2018
- Night cleaners deficient in vitamin D - Nov 2015
- 40 percent lower vitamin D level if work other shifts (Italy) – June 2015
- Night shift workers far more likely to have low vitamin D levels – May 2016
- Allergies and low vitamin D strongly associated with night shift bakers– Sept 2014
- Working other than dayshift reduces vitamin D levels and Bone Mineral Density and increases bone pain – Aug 2013
- Shift workers 23 percent more likely to have cardiovascular events – meta-analysis July 2012
- Shift work increases breast cancer risk by 22 percent (Vitamin D is 1 of 5 possible ways) – Oct 2013
Purpose: Epidemiological studies have suggested that indoor hospital employees, either day or night shift workers, are at high risk of metabolic and cardiovascular diseases. Interestingly, previous reports have also described a higher prevalence of vitamin D (25OHD) deficiency among these workers. However, few studies have determined the monthly variations in 25OHD levels in indoor hospital employees.
Methods: To address this lack of knowledge, in 2018, during the periodic health surveillance checks at the Service of Occupational Medicine, we measured 25OHD levels in a group of indoor hospital workers (88 rotating night shift workers vs 200 day workers). Each participant received a single annual health surveillance check.
Results: The mean levels of 25OHD were consistently below the lower limit of the normal range in both groups throughout the year. Only in the summer, day workers but not rotating night shift workers (mean 25.9 ± 11.3 ng/ml vs 23.1 ± 9.1 ng/ml; p = 0.042) showed levels significantly higher than those in the other seasons. This difference remained statistically significant even after correction for study covariates [β = - 1.649 (CI - 0.283/- 3.482), p = 0.039]. A cosinor analysis confirmed that the difference in the 25OHD levels between groups was present later in the year.
Conclusions: We found that relatively young healthy hospital workers, especially those with rotating night shifts, in the absence of significant metabolic risk factors, have a high risk of 25OHD deficiency/insufficiency. Because 25OHD deficiency may lead to a progression to more severe conditions such as osteoporosis or bone fractures, our results should be verified in larger cohorts including different ancestries.