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Pancreatic Cancer trials using Vitamin D and viral therapy – Nov 2018

A New Role for Vitamin D: The Enhancement of Oncolytic Viral Therapy in Pancreatic Cancer

Biomedicines 2018, 6(4), 104; https://doi.org/10.3390/biomedicines6040104
Christopher J. LaRocca and Susanne G. Warner
Department of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA
(This article belongs to the Special Issue Viruses in Cancer and Therapy)

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Oncolytic viruses have emerged as a novel class of anti-cancer therapeutics with one virus already receiving United States Food and Drug Administration (FDA) approval (talimogene laherparepvec) and many others undergoing testing in clinical trials. These viruses have direct lytic effects on tumor cells as well as immunomodulatory functions to increase inflammatory cell infiltrates in the tumor microenvironment. Despite all of the advances in cancer care, pancreatic cancer remains a highly lethal malignancy. One of the main barriers to successful systemic treatment of the disease is the fibrotic tumor stroma, as the unique extracellular matrix creates an environment that promotes tumor growth and is resistant to chemotherapy and other anti-cancer agents. The pleiotropic effects of Vitamin D have been widely studied, but recent research has now demonstrated it to be an effective agent in modulating pancreatic cancer stroma to facilitate the enhanced delivery of cytotoxic chemotherapy and immunogenicity in response to treatment. This review will explore the combination of Vitamin D with oncolytic viruses and how this novel application of Vitamin D’s ability to modulate pancreatic tumor stroma may result in a potential mechanism for increasing the efficacy of oncolytic virotherapy in pancreatic cancer.

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10795 Vitamin D and Viral Therapy in Pancreatic Cancer.pdf PDF 2018 admin 05 Nov, 2018 13:23 223.47 Kb 464
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