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Omega-3 reduces side effects of Cancer treatments – April 2019

Nutrients 2019, 11(5), 945; https://doi.org/10.3390/nu11050945
Raquel D. S. Freitas 1,2 and Maria M. Campos 1,2,3,*

 Download the PDF from VitaminDWiki]



Cachexia (Weakness or wasting of the body)



Omega-3 polyunsaturated fatty acids (PUFAs) are considered immunonutrients and are commonly used in the nutritional therapy of cancer patients due to their ample biological effects. Omega-3 PUFAs play essential roles in cell signaling and in the cell structure and fluidity of membranes. They participate in the resolution of inflammation and have anti-inflammatory and antinociceptive effects. Additionally, they can act as agonists of G protein-coupled receptors, namely, GPR40/FFA1 and GPR120/FFA4.
Cancer patients undergo complications, such as

  • anorexia-cachexia syndrome,
  • pain,
  • depression, and
  • paraneoplastic syndromes.

Interestingly, the 2017 European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines for cancer patients only discuss the use of omega-3 PUFAs for cancer-cachexia treatment, leaving aside other cancer-related complications that could potentially be managed by omega-3 PUFA supplementation. This critical review aimed to discuss the effects and the possible underlying mechanisms of omega-3 PUFA supplementation in cancer-related complications. Data compilation in this critical review indicates that further investigation is still required to assess the factual benefits of omega-3 PUFA supplementation in cancer-associated illnesses. Nevertheless, preclinical evidence reveals that omega-3 PUFAs and their metabolites might modulate pivotal pathways underlying complications secondary to cancer, indicating that this is a promising field of knowledge to be explored.

Created by admin. Last Modification: Tuesday June 25, 2019 18:08:07 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
12204 Cancer treatment Omega-3.pdf admin 25 Jun, 2019 372.34 Kb 498
12203 Cachexia.jpg admin 25 Jun, 2019 168.98 Kb 672
12202 Cancer Omega-3 T3.jpg admin 25 Jun, 2019 125.94 Kb 645
12201 Cancer Omega-3.jpg admin 25 Jun, 2019 81.20 Kb 1293
11872 Omega-3 cancer complications T1.jpg admin 30 Apr, 2019 148.52 Kb 892