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Omega-3 reduces side effects of Cancer treatments – April 2019

Nutrients 2019, 11(5), 945; https://doi.org/10.3390/nu11050945
Raquel D. S. Freitas 1,2 and Maria M. Campos 1,2,3,*

 Download the PDF from VitaminDWiki]
One of many tables in the study
Image

Omega-3 polyunsaturated fatty acids (PUFAs) are considered immunonutrients and are commonly used in the nutritional therapy of cancer patients due to their ample biological effects. Omega-3 PUFAs play essential roles in cell signaling and in the cell structure and fluidity of membranes. They participate in the resolution of inflammation and have anti-inflammatory and antinociceptive effects. Additionally, they can act as agonists of G protein-coupled receptors, namely, GPR40/FFA1 and GPR120/FFA4.
Cancer patients undergo complications, such as

  • anorexia-cachexia syndrome,
  • pain,
  • depression, and
  • paraneoplastic syndromes.

Interestingly, the 2017 European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines for cancer patients only discuss the use of omega-3 PUFAs for cancer-cachexia treatment, leaving aside other cancer-related complications that could potentially be managed by omega-3 PUFA supplementation. This critical review aimed to discuss the effects and the possible underlying mechanisms of omega-3 PUFA supplementation in cancer-related complications. Data compilation in this critical review indicates that further investigation is still required to assess the factual benefits of omega-3 PUFA supplementation in cancer-associated illnesses. Nevertheless, preclinical evidence reveals that omega-3 PUFAs and their metabolites might modulate pivotal pathways underlying complications secondary to cancer, indicating that this is a promising field of knowledge to be explored.

Created by admin. Last Modification: Wednesday May 1, 2019 16:35:21 GMT-0000 by admin. (Version 4)

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11872 Omega-3 cancer complications T1.jpg admin 30 Apr, 2019 13:33 148.52 Kb 17
11871 nutrients-11-00945.pdf PDF 2019 admin 30 Apr, 2019 13:17 2.01 Mb 3
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