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Breast cancer cells killed synergistically by Vitamin D plus Omega-3 (lab) – June 2017

Vitamin D enhances omega-3 polyunsaturated fatty acids-induced apoptosis in breast cancer cells.

Cell Biol Int. 2017 Jun 19. doi: 10.1002/cbin.10806. [Epub ahead of print]


Yang J1,2, Zhu S1,2, Lin G1,2, Song C1,2, He Z1,2,3.

  • 1 State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, China.
  • 2 Synergistic Innovation Center for Food Safety and Nutrition, Jiangnan University, Wuxi, 214122, China.
  • 3 School of Medicine, Jiangnan University, Wuxi, 214122, China.

Breast cancer is a leading type of cancer in women and generally classified into three subtypes of ER+ /PR+ , HER2+ and triple negative. Both omega-3 polyunsaturated fatty acids and vitamin D3 play positive role in the reduction of breast cancer incidence. However, whether combination of omega-3 polyunsaturated fatty acids and vitamin D3 has stronger protective effect on breast carcinogenesis still remains unknown. In this study, we show that the combination of ω-3 free fatty acids (ω-3 FFAs) and 1α, 25-dihydroxy-vitamin D3 (VD3 ) dramatically enhances cell apoptosis among three subtypes of breast cancer cell lines. Bcl-2 and total PARP protein levels are decreased in combined treatment MCF-7 and SK-BR-3 cells. Caspase signals play a vital role in cell apoptosis induced by combination. Moreover, Raf-MAPK signaling pathway is involved in the apoptosis induction by combination of ω-3 FFAs+VD3 . These results demonstrate that the induction of cell apoptosis by combined treatment is dependent on different signaling pathways in three subtypes of breast cancer cell lines.

PMID: 28627723 DOI: 10.1002/cbin.10806

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Was on Sci-Hub.tv March 2018

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