The unpredictability of seasonal variations in serum vitamin D levels in children with asthma and/or rhinitis
Allergologia et Immunopathologia, https://doi.org/10.1016/j.aller.2019.01.002
Miceli Sopoa G.Cerchiaraa G.Bersania S.Monacoa A.Romanoa A.Posciab
A Allergy Unit, Pediatrics Area, Department of Woman and Child Health, Policlinico Gemelli Universitary Foundation IRCCS, Catholic University of Sacred Heart, Rome, Italy
B Public Health Institute, Catholic University of Sacred Heart, Rome, Italy
- Vitamin D levels should be adjusted for season (Cosinor) – Nov 2015
- Most studies "adjust" all Vitamin D levels with season
- This adjustment often might be incorrect
- Black infants had far lower vitamin D levels which did not vary with season – Jan 2013
- Some people need more vitamin D to get the same response – perhaps due to genes – Nov 2014
- Search VitaminDWiki for "SEASONALLY ADJUSTED" 58 studies as of April 2019
Background: Some studies have showed that seasonality is an important determinant of vitamin D (vitD) status.
Objective: We evaluated whether there are differences in individual trends of serum vitD level over one year in asthmatic and rhinitic children.
Materials and methods
Ninety-two asthmatic and rhinitic paediatric patients were followed up for one year and their serum vitD level was detected at three-month intervals, once in each season.
We observed higher vitD levels at the end of summer and lower at the end of winter. However, the individual seasonal trend was very variable and unpredictable. If it is true that in a given season the majority of patients followed one direction (increase or decrease of serum vitD levels), nevertheless a substantial percentage behaved differently and unpredictably.
- at the end of spring,
70% of patients showed an increase in serum vitD levels, but
30% showed a decrease. In addition,
- five individuals had a value ≥50 ng/ml in September and
showed serum vitD levels ≥30 ng/ml throughout the year;
- 16 patients presented vitD value ≥40 ng/ml in September
and always had ≥20 ng/ml in the other months.
The wide and unpredictable variability of the individual trend of serum vitD levels should be taken into account before deciding whether or not a drug supplementation is appropriate.