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Lung Cancer and Vitamin D – no consensus over 20 prospective studies – April 2018

No association between circulating concentrations of vitamin D and risk of lung cancer: An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3).

Ann Oncol. 2018 Apr 2. doi: 10.1093/annonc/mdy104. [Epub ahead of print]

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Muller DC1,2, Hodge AM3,4, Fanidi A1,5, Albanes D6, Mai XM7, Shu XO8, Weinstein SJ6, Larose TL1,9, Zhang X10, Han J11,12, Stampfer MJ10,13,14, Smith-Warner SA13,14, Ma J10, Gaziano JM15,16,17, Sesso HD13,15,16, Stevens VL18, McCullough ML18, Layne TM6, Prentice R19, Pettinger M19, Thomson CA20, Zheng W8, Gao YT21, Rothman N6, Xiang YB22, Cai H23, Wang R24, Yuan JM24,25, Koh WP26, Butler LM25,27, Cai Q23, Blot WJ23, Wu J23, Ueland PM28,29, Midttun Ø30, Langhammer A31, Hveem K9,31, Johansson M32, Hultdin J33, Grankvist K33, Arslan AA34,35, Le Marchand L36, Severi G3,37,38, Johansson M1, Brennan P1.

There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in pre-diagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3).

The study included 5,313 lung cancer cases and 5,313 controls selected from. Blood samples for the cases were collected, on average, 5 years prior to lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in 5 categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 (25(OH)D2) and 25-hydroxyvitamin D3 (25(OH)D3) and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) for 25(OH)D as both a continuous and categorical variable.

Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% confidence interval: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology.

This study did not support an association between vitamin D concentrations and lung cancer risk.

PMID: 29617726 DOI: 10.1093/annonc/mdy104

Created by admin. Last Modification: Thursday April 5, 2018 22:12:46 GMT-0000 by admin. (Version 5)

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