Loading...
 
Translate Register Log In Login with facebookLogin and Register

Lung Cancer risk decreased 2.4 percent with every 100 IU Vitamin D extra intake – meta-analysis Sept 2018

Associations of the risk of lung cancer with serum 25-hydroxyvitamin D level and dietary vitamin D intake: A dose-response PRISMA meta-analysis.

Medicine (Baltimore). 2018 Sep;97(37):e12282. doi: 10.1097/MD.0000000000012282.
Wei H1, Jing H1, Wei Q1, Wei G1 guowei88688 at 126.com, Heng Z2 hengzhou117 at 163.com
1 Department of Radiology, the Fifth Hospital of Wuhan.
2 Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.

 Download the PDF from VitaminDWiki
The associations of the risk of lung cancer with the vitamin D intake and serum level are controversial. We performed a comprehensive dose-response meta-analysis to evaluate the precise relationships between the above mentioned parameters.We performed a web search of the PubMed, Medline, and Embase databases to identify potential studies that evaluated the relationships between vitamin D intake or serum 25-hydroxyvitamin D (25(OHD) levels and the risk of lung cancer on December 5, 2017. According to the inclusion and exclusive criteria, 16 studies were included in this meta-analysis. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were used to assess the strength of the associations. A dose-response analysis was conducted to quantitate the relationship between the serum 25(OH)D or vitamin D intake and the risk of lung cancer.
The pooled RR (highest level vs lowest level) showed that the serum 25(OH)D level was not associated with the risk of lung cancer (RR = 1.046, 95% CI = 0.945-1.159). A high vitamin D intake was inversely correlated with the lung cancer risk (RR = 0.854, 95% CI = 0.741-0.984). No significant dose-response relationship was observed between the serum 25(OH)D level and the lung cancer risk. The linearity model of the dose-response analysis indicated that with every 100 IU/day increase in vitamin D intake, the risk of lung cancer decreased by 2.4% (RR = 0.976, 95% CI = 0.957-0.995, P = .018).A high vitamin D intake provides limited protection against lung cancer carcinogenesis.

Created by admin. Last Modification: Wednesday February 5, 2020 16:14:07 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
13453 Associations_of_the_risk_of_lung_cancer_with_serum.43.pdf PDF 2018 admin 05 Feb, 2020 16:10 395.62 Kb 57
See any problem with this page? Report it (FINALLY WORKS)