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Low Level Laser therapy and photobiomodulation proven to help health for many years – May 2020

Sunlight and Health: Shifting the Focus From Vitamin D3 to Photobiomodulation by Red and Near-Infrared Light

Review Ageing Res Rev. 2020 May 25;101089. doi: 10.1016/j.arr.2020.101089
Vladimir Heiskanen 1 valtsu.heiskanen at gmail.com, Morgan Pfiffner 2, Timo Partonen 3


A decade of very positive personal experience with Low Level Laser Therapy
The founder of VitaminDWiki designed and bullt an LLLT for his wife's lymphedema which resulted from Breast Cancer treatments.
My LLLT was designed to shine flashing 902 nanometer infrared light as deep as 2 inches into the body,
An LLLT book from Russia indicated that the on/off flashing far more important than just the intensity of light.
My LLLT flashes the light 100,000 times per second
Since 2009 (before starting VitaminDWiki) it worked well for lymphedema as well as many other health problems that are near to the surface of the skin.

LLLT treatment has more variables than Vitamin D
I expect it will take at least another decade for the medical profession to come to use it

  • Frequency of light
    • Perhaps multiple frequencies could be used concurrently
  • Intensity of Light
  • Intensity modulation of light while it is on
  • Use of pulsed light to get far deeper into the body
  • Pulsing of light to improve benefit over that of just intensity
    • Duty cycle might be important
    • varying the pusle rate might be important - the cells "get used" toa constant rate
  • When the treatment is given (appears that just before bedtime is great)
  • How many different sites on the body is treated at a session
    • It appears that too many sites results in less healing focus by the body

 Download the PDF from Sci-Hub via VitaminDWiki

Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast body of randomized controlled trials (RCTs) and Mendelian randomization studies have failed to confirm any major health benefits from vitamin D supplementation. In this review, we present tentative evidence showing that red and near-infrared light, both being present in sunlight, could explain the associations between sunlight exposure and better health status. Body irradiation with red and near-infrared light, usually termed as photobiomodulation (PBM), has demonstrated beneficial effects in animal models of chronic diseases. Beyond this, preliminary evidence from RCTs suggest potential clinical benefit from PBM for chronic diseases. PBM is currently being investigated in many pre-registered clinical trials, results of which will eventually clarify the role of red and near-infrared light in the prevention and treatment of common age-related chronic diseases.

Clipped from the PDF

The exact mechanisms for these effects are not well known, though preliminary evidence suggests
possible roles for mitochondrial cytochrome c oxidase and photolabile sources of nitric oxide
(Serrage et al., 2019). The existence of mitochondria-related mechanism is supported by studies
reporting photobiomodulation-induced changes in ATP levels, mitochondrial membrane potential
(ΔΨm), cytochrome c oxidase activity, oxygen consumption and activity of SIRT1/PGC1α pathway,
as well as protection of mitochondria against toxins such as potassium cyanide and tetrodotoxin
(Hamblin, 2018; Wong-Riley et al., 2005; Zhang et al., 2020).

Currently, the scientific literature concerning PBM encompasses more than 4,500 scientific articles,
including more than 1500 animal trials and 700 randomized clinical trials. The publication rate of PBM
research has increased rapidly during the 21st century, and the current publication rate is
approximately 500 new articles annually (Figure 1)

The overview is based on a personal database of approximately 4700 scientific articles related to PBM,
compiled by manual literature search (http://www.bitly.com/PBM-database; Accessed on 3 March 2020

Created by admin. Last Modification: Saturday May 30, 2020 21:51:00 GMT-0000 by admin. (Version 11)

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13869 LLLT studies.jpg admin 30 May, 2020 16:21 80.89 Kb 185
13867 Photobiomodulation_compressed.pdf PDF 2020 admin 29 May, 2020 13:04 237.24 Kb 1247
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