Immune system and vitamin D (from kidney doctor’s point of view) – Feb 2014

Vitamin D and the Immune System from the Nephrologist's Viewpoint

Immune system and vitamin D ( N viewpoint) – Feb 2014
ISRN Endocrinology, Volume 2014 (2014), Article ID 105456, 11 pages. http://dx.doi.org/10.1155/2014/105456
Cheng-Lin Lang,1 Min-Hui Wang,2 Chih-Kang Chiang,3 and Kuo-Cheng Lu2
1Department of Internal Medicine, Cardinal Tien Hospital, Yonghe Branch, New Taipei 23445, Taiwan
2Division of Nephrology, Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, 362 Chung-Cheng Road, Hsin-Tien District, New Taipei 23148, Taiwan
3Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 10002, Taiwan

Received 25 October 2013; Accepted 4 December 2013; Published 22 January 2014

Vitamin D and its analogues are widely used as treatments by clinical nephrologists, especially when treating chronic kidney disease (CKD) patients with secondary hyperparathyroidism. As CKD progresses, the ability to compensate for elevations in parathyroid hormone (PTH) and fibroblast growth factor-23 and for decreases in 1,25(OH)2D3 becomes inadequate, which results in hyperphosphatemia, abnormal bone disorders, and extra-skeletal calcification. In addition to its calciotropic effect on the regulation of calcium, phosphate, and parathyroid hormone, vitamin D has many other noncalciotropic effects, including controlling cell differentiation/proliferation and having immunomodulatory effects. There are several immune dysregulations that can be noted when renal function declines. Physicians need to know well both the classical and nonclassical functions of vitamin D. This review is an analysis from the nephrologist's viewpoint and focuses on the relationship between the vitamin D and the immune system, together with vitamin's clinical use to treat kidney diseases.

---

Figure 2: Innate Immune system

Figure 3: Adaptive immune system

Vitamin D and adaptive immune system. The adaptive immune system is like Tai-Chi, namely, that it separates the Yin and the Yang.
1,25(OH) 2D3 directly modulates T cell responses and polarization related to the inflammatory molecules Th1 and Th17 in order to give rise to protective Th2 and Treg cells. In addition, 1,25(OH) 2D3 also inhibits the inflammatory Th1 and Th17 cytokines and upregulates the protective Th2 and Treg cytokines. When these effects are integrated, the adaptive immune system may produce lower levels of inflammation, atherosclerosis, and autoimmunity.
PDF is attached at the bottom of this page

See also VitaminDWiki

• Overview Kidney and vitamin D
• Immunity category starts with

269 items in Immunity category

    see also

Virus category listing has 1383 items along with related searches

Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
228 VitaminDWiki pages contained "infection" in title (June 2024)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
   Only the brain is more complex, nothing about Vitamin D
18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection

51 studies are in both Immunity and Virus categories