Plasma 25-hydroxyvitamin D Is Positively Associated With Folate and Vitamin B 12 Levels in Adolescents
Nutr Res. 2020 Jun 6;79:87-99. doi: 10.1016/j.nutres.2020.06.003
Abdur Rahman 1, Abdullah Al-Taiar 2, Lemia Shaban 3, Reem Al-Sabah 4, Olusegun Mojiminiyi 5
Note: Many doctors prescribing high doses of Vitamin D also prescribe Vitamin B-12
- 5X difference in B-12 bioavailability (emulsion best)
- Tested German pregnancies for 27 deficiencies, B-12 deficiency was found most frequently - June 2018
- 3 out of 4 Vegans are deficient, 1 out of 4 elderly
Vitamin B12 in VitaminDWikiincludes the following
Vitamin B12 is not a cofactor of Vitamin D, but it is often needed with Vitamin D
Surfing the web finds
- B12 deficiency increases with age
- B12 appears to have no toxic upper limit
- Some people get frequent B12 injections or I.V, to restore levels
- Injection may not be needed
- Only a small portion of B12 taken orally gets into the bloodstream
- Sublingual B12 may not have that problem
- B12 is stored in the liver – half-life of > 2 years - But. Dr. Greger says to take it weekly or daily
- B12 deficiency symptoms include poor gut - which can reduce uptake of Vitamin D
- unless use gut-friendly forms of Vitamin D, including topical
- B12 can be supplemented via pills, sublingual, transdermal patch, injection, emulsion, and spray
- As with Vitamin D, a massive (loading) dose can restore levels quickly
- Nano forms of B12 are more bio-available - as with many other supplements
- Vitamin D and Folate fortification of foods - April 2012
- Vitamin D is 100X better than folic acid during pregnancy
- Dr. Coimbra interview covering Vitamin D, Magnesium, Folate, Vaccines - Oct 2018 in Portuguese
- Off topic: Folic Acid - the horror story (for a small percentage of people) - Sept 2013
- Note: Folic Acid is not Folate
Download the PDF from sci-hub VitaminDWiki
Higher Vitamin D is 35% more likely if higher Vitamin B12
Vitamin D affects the absorption of folate in vitro, and perhaps of vitamin B12 (B12). However, epidemiological studies on the association of vitamin D with folate and B12 are inconclusive. We hypothesized a positive association of plasma 25-hydroxyvitamin D 25(OH)D with folate and B12 levels in adolescents. This hypothesis was tested in a cross-sectional study of healthy adolescents (11-16 years old; n = 1416), selected from public middle schools from across Kuwait, using stratified multistage cluster random sampling. Plasma 25(OH)D was measured by LC-MS/MS. Serum B12 and total folate in hemolyzed whole blood were analyzed with commercial kits; RBC and plasma folate were calculated from total folate. Data on potential confounders were collected from the parents and adolescents. In a univariable model, 25(OH)D as a continuous variable was positively associated with each of total, RBC, and plasma folate (P < .001). After adjusting for potential confounders, this association remained significant with total folate (β = 2.0, P < .001) and red blood cell folate (β = 1.8, P < .001), but not with plasma folate (β = 0.2, P = .34). A similar pattern of association was evident when 25(OH)D was fitted as categorical variable. Correlation between B12 and 25(OH)D was weak but significant (ρ = 0.1, P < .001). 25(OH)D was positively associated with B12 in both univariable and multivariable models (P < .001) when fitted as a categorical variable only. Simultaneous quantile regression confirmed these results.
We conclude that plasma 25(OH)D is positively associated with folate and B12 levels in adolescents. Properly designed large-scale randomized controlled trials are warranted to investigate the causal role of vitamin D in folate and B12 absorption.
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