Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN ('Seguimiento Universidad de Navarra') Project
Nutrients. 2022 Jun 21;14(13):2561. doi: 10.3390/nu14132561.
Rodrigo Sánchez-Bayona 1 2, Maira Bes-Rastrollo 2 3 4, Cesar I Fernández-Lázaro 2 4, Maite Bastyr 2, Ainhoa Madariaga 1, Juan J Pons 4 5, Miguel A Martínez-González 2 3 4, Estefanía Toledo 2 3 4
The maximum intake from food, sun, and supplement was 500 IU/day
Obesity is associated with a higher risk of several types of cancer, grouped as obesity-related cancers (ORC). Vitamin D deficiency is more prevalent in obese subjects, and it has been suggested to play a role in the association between obesity and cancer risk. The aim of the study was to analyze the association between vitamin D intake and the subsequent risk of ORC in a prospective Spanish cohort of university graduates. The SUN Project, initiated in 1999, is a prospective dynamic multipurpose cohort. Participants answered a 556-item lifestyle baseline questionnaire that included a validated food-frequency questionnaire. We performed Cox regression models to estimate the hazard ratios (HRs) of ORC according to quartiles of energy-adjusted vitamin D intake (diet and supplements). We included 18,017 participants (mean age = 38 years, SD = 12 years), with a median follow-up of 12 years. Among 206,783 person-years of follow-up, we identified 225 cases of ORC. We found no significant associations between vitamin D intake and ORC risk after adjusting for potential confounders: HRQ2vsQ1 = 1.19 (95% CI 0.81-1.75), HRQ3vsQ1 = 1.20 (95% CI 0.81-1.78), and HRQ4vsQ1 = 1.02 (95% CI 0.69-1.51). Dietary and supplemented vitamin D do not seem to be associated with ORC prevention in the middle-aged Spanish population.
Download the PDF from VitaminDWiki
“obesity-related cancers”(ORC)
esophageal adenocarcinoma, postmenopausal breast carcinoma, colon and rectum,
uterus, gallbladder, stomach, kidney, liver, ovary, pancreas, thyroid, meningioma, and multiple myeloma
VitaminDWiki Obesity pages with CANCER in title (8 as of July 2022)
This list is automatically updated