27 percent less likely to develop diabetes if prediabetic and have adequate vitamin D – Mar 2012

Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Program.

Diabetes Care. 2012 Mar;35(3):565-73. Epub 2012 Feb 8.
Pittas AG, Nelson J, Mitri J, Hillmann W, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B; Diabetes Prevention Program Research Group.
Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, Boston, Massachusetts, USA. apittas at tuftsmedicalcenter.org

OBJECTIVE:
To investigate the association between vitamin D status, assessed by plasma 25-hydroxyvitamin D, and risk of incident diabetes.

RESEARCH DESIGN AND METHODS:
Prospective observational study with a mean follow-up of 2.7 years in the Diabetes Prevention Program (DPP), a multicenter trial comparing different strategies for prevention of diabetes in patients with prediabetes.

We assessed the association between plasma 25-hydroxyvitamin D, measured repeatedly during follow-up, and incident diabetes in the combined placebo (n = 1,022) and intensive lifestyle (n = 1,017) randomized arms of the DPP.

Variables measured at multiple study time points (25-hydroxyvitamin D, BMI, and physical activity) entered the analyses as time-varying "lagged" covariates, as the mean of the previous and current visits at which diabetes status was assessed.

RESULTS:
After multivariate adjustment, including for the DPP intervention, participants in the highest tertile of 25-hydroxyvitamin D (median concentration, 30.1 ng/mL) had a hazard ratio of 0.72 (95% CI 0.56-0.90) for developing diabetes compared with participants in the lowest tertile (median concentration, 12.8 ng/mL).

The association was in the same direction in placebo (0.70; 0.52-0.94) versus lifestyle arm (0.80; 0.54-1.17).

CONCLUSIONS:
Higher plasma 25-hydroxyvitamin D, assessed repeatedly, was associated with lower risk of incident diabetes in high-risk patients, after adjusting for lifestyle interventions (dietary changes, increased physical activity, and weight loss) known to decrease diabetes risk. Because of the observational nature of the study, the potential association between vitamin D and diabetes needs to be confirmed in intervention studies.

PMID: 22323410

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See also VitaminDWiki

• Prediabetes treated by Vitamin D (34 ng, 3500 IU per day) – meta-analysis May 2018
• Overview Diabetes and vitamin D
• All items in Diabetes and Vitamin D 553 items
• Search VitaminDWiki for prediabetes OR prediabetic 473 items as of June 2018

See also web

• Natural Health 365 on Pre-diabetes July 2012
  pre-diabetes = fasting level between 100 and 125mg/dl.
  pre-diabetics have a 50 percent higher risk for developing heart disease and stroke vs. non-diabetics.
  79 million of US adults have pre-diabetes = 39% increase from 2008.
• CDC Diabetes Statistics for 2011
  25.8 million US = 8% have diabetes, Diagnosed: 18.8 million, Undiagnosed: 7.0 million
  Age 65 years or older: 10.9 million, or 27%
• CDC Pre-diabetes
  1 of every 3 U.S. adults had prediabetes in 2010
  If you have prediabetes, you are 5 to15 times more likely to develop type 2 diabetes