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Evidence for Vitamin D - Grant Aug 2011

by Dr. William Grant, unpublished work in progress,

for Vitamin D Council as of Aug 2011


PubMed = Aug 8, 2011 PubMed.gov , words in title and/or abstract;
  for cancer, the first number is a search using “vitamin D” and “breast cancer”
  while the second number is a search using “vitamin D”, “breast” and “cancer”
  PM2 = Feb, 2011, not updated in Aug, 2011
E = Ecol = ecological studies
O = Obser = observational studies,
R = RCT = randomized controlled trial (or used in treatment with positive results)
S = Strong Evidence = * = some combination of ecological, observational, cross-sectional studies,
  and/or randomized controlled trials (RCTs) and possibly an understanding of the mechanisms.
  Since solar UVB is the primary source of vitamin D, he does not consider it necessary to have a supporting RCT.
M = Mod = moderate strength evidence
A =Assoc. = associated effects of low vitamin D due to comorbid diseases or treatment.

Disease PubMed Ecol Obser RCT Strong Mod Weak Assoc
Acne 15 A
Amyotrophic lateral sclerosis 7 W
Anaphylaxis - food allergy 8 E O M
Anemia * 165 O R S
Ankylosing spondylitis 22 A
Anxiety 30 W
Asthma {moving toward strong} 134 O R M
Atopic dermatitis - eczema 24 O R M
Atherosclerosis * 158 O S
Autism 21 E O M
Bacterial vaginosis * 7 O S
Benign prostate hyperplasia 12 O W
Biliary cirrhosis - primary (PBC) 101 E M
Birth defects 6 W
Bronchitis 2
Cancer * - All 2485 E O R S
Cancer -Bladder * 21/43 E S
Cancer - Brain 0/19 E M
Cancer - Breast * 540/667 E S
Cancer - Cervical 9/18 E
Cancer - Colon 228/339
Cancer - Colorectal * 244 E S
Cancer - Endometrial * 18/29 E S
Cancer - Esophageal * 6/17 E S
Cancer - Eye (uveal) 3/8
Cancer - Gallbladder * 2 /8 E S
Cancer - Gastric * 15/29 E S
Cancer - Head & neck 5 /21
Cancer - Hodgkin disease *27 PM2 E S
Cancer - Leukemia 306 E M
Cancer - Liver 3 /59
Cancer - Lymphoma 94
Cancer - Lung 56/99 E M
Cancer - Melanoma 166 E M
Cancer - Multiple myeloma 61 O W
Cancer - Non-Hodgkin's lymphoma * 24 E S
Cancer - Non-melanoma skin 16
Cancer - Ovarian * 60/94 E S
Cancer - Pancreatic 43/60 E M
Cancer - Prostate 577/688 E M
Cancer - Rectal 30/65
Cancer - Renal * 6/121 E S
Cancer - Vulvar * 0/2 E S
Cardiac arrhythmia 2
Cardiovascular (disease) * 979 O S
Celiac disease 86 A
Chronic kidney failure * 627 O S
Chronic liver disease 51 W A
Chronic or diffuse muscle pain20 PM2
Chronic obstructive pulmonary disease 48 O M
Cognitive impairment 28 O M
Common cold R M
(Congestive) heart failure 141 O M
Coronary heart disease * 59 O S
Craniotabes 20
Cystic fibrosis 106 O R W
Dementia 66 W
Dental caries * 36 E O S
Depression 163 O M
Diabetes - type 1196 PM2 O M
Diabetes - type 2 *904 PM2 O S
Diabetes 1006
Epilepsy 100 O W A
Fabry disease 3
Falls or fractures (see also Osteo) * 263 O R S
Fertility - regular menses 48 O M A
Fibromyalgia 23 O R W
Gaucher disease 6
Headache - tension 16 O M
Hepatitis 92
HIV/AIDS 135 E O R M
Hypercalcemia 1205
Hypertension 476 E O R M
IBD or Crohn's or Colitis * 152 E O S A
Influenza * 42 E O R S
Insulin resistance * 185 O R S
Kidney stones 44 A
Learning (disorders) 21
Leprosy 18
Lupus 125 A
Meningococcal dis. - meningitis * 4 E S
Multiple sclerosis * 366 O S
Muscular weakness146 PM2 O
Myopathy * 84 S
Myositis 9
Neutropenia 9
Osteitis deformans 0
Osteoarthritis 105 W
Osteomalacia 1198
Osteopenia 678
Osteoporosis * 3448 O R S
Paget's bone disease 58 O R M
Pancreatitis 39
Parkinson's disease 43 O M
Pelvic floor status 2
Periodontal disease 64 O M
Peripheral vascular disease 12 O M
Pneumonia * 37 E R S
Polycystic ovary syndrome * 18 O R S
Preeclampsia * 38 O S
Premature birth & low birth weight 165
Psoriasis - psoriatic arthritis 371 R M
Renal failure 822
Renal osteodystrophy 344
Respiratory tract infections 18
Rheumatoid arthritis 222 O A
Rickets * 2155 R S
Rosacea 6 A
Schizophrenia 73 E M
Seasonal affective disorder 8
Sepsis/septicemia * 40 E O S
Sickle cell disease 20 A
Spinal stenosis 6
Stroke 106 O M
Systemic sclerosis 15
Thalassaemia 16
Thrombosis 32 O M
Tonsillitis 2 M
Tuberculosis * 259 O R S
Turner syndrome 5
Vitiligo vulgaris 27 None
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Note: additional evidence for a disease can be added by looking at

See also VitaminDWiki


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