World J Gastrointest Oncol. 2011 Aug 15;3(8):123-7.
Kang W, Lee S, Jeon E, Yun YR, Kim KH, Jang JH. juhjang at inha.ac.kr
Wonmo Kang, Sujin Lee, Eunyi Jeon, Ye-Rang Yun, Jun-Hyeog Jang, Department of Biochemistry, School of Medicine, Inha University, Incheon 400-712, South Korea.
Colorectal cancer is a common cancer and the fourth leading cause of death in Korea. The incidence and mortality of colorectal cancer varies according to risk factors, such as age, family history, genetic history, food habits, and physical activities. Some studies have focused on the association between vitamin D and colorectal cancer. Today, there is growing evidence that high vitamin D intake and a plasma level of 25(OH)D(3) reduce the incidence of colorectal cancer by modifying cancer angiogenesis, cell apoptosis, differentiation, and proliferation. Taken together, these results suggest that vitamin D supplementation alone, or in combination with anti-cancer agents, might reduce the incidence of colorectal cancer. In this review, we discuss the function and mechanism of vitamin D including the effect of vitamin D on colorectal cancer.
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