Vieth R. rvieth at mtsinai.on.ca
Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):681-91.
Department of Nutritional Sciences, University of Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada; Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, Canada M5G 1X5.
The Institutes of Medicine (IOM) recently revised the recommended dietary allowances (RDA) for vitamin D, to maintain serum 25-hydroxyvitamin D (25(OH)D) at or above 50 nmol/L, to sustain bone density, calcium absorption, and to minimize risk of osteomalacia and rickets. However there are compelling reasons why 25(OH)D should preferably exceed 75 nmol/L:
- (A) Scrutiny of actual data specified by the IOM relating 25(OH)D to bone density and osteomalacia shows the desirable minimum 25(OH)D to be 75 nmol/L (30 ng/mL).
- (B) Humans are primates, optimized through evolution to inhabit tropical latitudes, with serum 25(OH)D over 100 nmol/L.
- (C) Epidemiologic relationships show health benefits if 25(OH)D levels exceed 70 nmol/L; these include
- fewer falls,
- better tooth attachment,
- less colorectal cancer,
- improved depression and wellbeing.
Some studies of populations at high-latitude relate higher 25(OH)D to risk of
- prostate cancer,
- pancreatic cancer or
Those relationships are attributable to the dynamic fluctuations in 25(OH)D specific to high latitudes,
and which can be corrected by maintaining 25(OH)D at steady, high levels throughout the year, the way they are in the tropics.
- (D) There are now many clinical trials that show benefits and/or no adversity with doses of vitamin D that raise serum 25(OH)D to levels beyond 75 nmol/L.
Together, the evidence makes it very unlikely that further research will change the conclusion that risk of disease with serum 25(OH)D higher than 75 nmol/L is lower than the risk of disease if the serum 25(OH)D is approximately 53 nmol/L.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Fig. 2. Bone mineral density data for Americans, from the NHANES Study of the US Population, for White, African American, and Spanish Americans (top to bottom). The lines are non-parametric curve fits, similar to running averages of BMD for subjects having the 25(OH)D levels along the horizontal axis. These lines show bone densities for men and women < age 50. BMD at the origin is set to 0 to cancel out density differences among the groups.
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- Google Search for Veith on VitaminDWiki more than 100 hits Nov 2011
- Race vs vitamin D level in Canadian Winter - Veith May 2011
- Overview Deficiency of vitamin D
- Review of Vitamin D Deficiencies in developing countries - Oct 2011
- Vitamin D Recommendations which has the following
- Institute of Medicine US Nov 2010 20ng/ml
- Osteoporosis Canada Sept 2010 >30ng/ml
- USANA 50 ng/ml with graph
- Need 30-60 ng of vitamin D for good health – Grant Jan 2011
- 1800 to 4000 IU vitamin D to get 30 to-44 ng no risk osteo - July 2010.pdf file
- More than 40 ng vitamin D for Athletes – July 2010
- USDA vitamin D level more than 30ng and 600 mg Calcium - March 2010
- Hypothesis - 40 ng is enough vitamin D if high latitude or dark skin derived from Veith
- The MINIMUM recommendation by 25 experts was higher than the Institute of Medicine