Increases in plasma 25(OH)D levels are related to improvements in body composition and blood pressure in middle-aged subjects after a weight loss intervention: Longitudinal study
Clinical Nutrition, Volume 34, Issue 5, October 2015, Pages 1010–1017, doi:10.1016/j.clnu.2014.11.004
Idoia Ibero-Baraibara, , Santiago Navas-Carreteroa, b, , Itziar Abetec, , J.A. Martineza, b, jalfmtz at unav.es , M.A. Zuleta, b,
The trial results are NOT a surprise
- During weight loss a 1 percent decrease in fat resulted in 1 percent increase in vitamin D levels - June 2015
- Weight loss of at least 10 percent resulted in 5 ng increase in vitamin D levels – Sept 2012
- Overweight and obese lost 12 lbs with vitamin D in 6 months– RCT May 2015
- Dieters lost 5 more pounds if achieved more than 32 ng of vitamin D – RCT March 2014
- Overview Obesity and Vitamin D
- Inflammatory diseases: review of vitamin D, with many tables – May 2014
- Inflammation and Vitamin D several studies
The aim of this study is to further clarify the role of plasma 25(OH)D concentration after a weight-lowering nutritional intervention on body composition, blood pressure and inflammatory biomarkers in overweight/obese middle-aged subjects.
Methods: This longitudinal research encompassed a total of 50 subjects [57.26 (5.24) year], who were under a 15% energy restricted diet for 4 weeks. Anthropometric and body composition variables, blood routine, inflammatory markers as well as 25(OH)D were analysed.
Results: Circulating 25(OH)D levels [12.13(±17.61%)] increased while anthropometric, body composition, routine blood markers as well as the concentration of TNF-α, C-reactive protein and Lp-PLA2 were significantly reduced after the intervention.
Multiple linear regression analyses evidenced that Δ25(OH)D increase was linked to the
- decrease in weight,
- SBP and IL-6 levels.
Moreover, a relationship was found between Δ25(OH)D, Δfat mass (r = −0.405; p = 0.007), ΔSBP (r = −0.355; p = 0.021) and ΔIL-6 (r = −0.386; p = 0.014). On the other hand, a higher increase in 25(OH)D was accompanied by reductions in weight, BMI, SBP, IL-6 and an increase in bone mineral concentration (p < 0.05).
Interestingly, higher levels of 25(OH)D at the endpoint, showed a significantly higher decrease in weight, BMI and total fat mass.
Conclusions: The increase in plasma 25(OH)D level is linked with the decrease in SBP and adiposity in middle-aged subjects after a weight-loss intervention. Therefore, 25(OH)D assessment is a potential marker to be accounted in metabolic measures related to blood pressure, adiposity and inflammation in obesity management.