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During weight loss a 1 percent decrease in fat resulted in 1 percent increase in vitamin D levels - June 2015

Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men.

Int J Obes (Lond). 2015 Jun 22. doi: 10.1038/ijo.2015.118. [Epub ahead of print]
Gangloff A1, Bergeron J2, Pelletier-Beaumont E3, Nazare JA4, Smith J5, Borel AL6, Lemieux I5, Tremblay A3, Poirier P7, Alméras N3, Després JP3.
11] Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada [2] Lipid Research Center, CHU de Québec Research Center, Québec, QC, Canada.
2Lipid Research Center, CHU de Québec Research Center, Québec, QC, Canada.
31] Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada [2] Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, QC, Canada.
41] Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada [2] Centre Européen pour la Nutrition et la Santé (CENS), CarMeN Laboratory, Pierre-Bénite, France.
5Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada.
61] Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada [2] Endocrinology Department, University Hospital, Grenoble, France [3] INSERM U1042, Grenoble, France [4] University Grenoble Alpes, Grenoble, France.
71] Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada [2] Faculty of Pharmacy, Université Laval, Québec, QC, Canada.

BACKGROUND/OBJECTIVES:
Although weight loss has been associated with changes in circulating 25-hydroxyvitamin D (25(OH)D) levels, the quantification of the increase in 25(OH)D levels as a function of adipose tissue volume loss precisely assessed by imaging has not been reported before. The objective of this substudy was to describe the effects of a 1-year lifestyle intervention on plasma 25(OH)D levels. The relationships between changes in 25(OH)D levels and changes in adiposity volume (total and by adipose tissue compartment) were studied.

SUBJECTS/METHODS:
This intervention study was performed between 2004 and 2006 and participants were recruited from the general community. Sedentary, abdominally obese and dyslipidemic men (n=103) were involved in a 1-year lifestyle modification program. Subjects were individually counselled by a kinesiologist and a nutritionist once every 2 weeks during the first 4 months with subsequent monthly visits in order to elicit a 500 kcal daily energy deficit and to increase physical activity/exercise habits. Body weight, body composition, and fat distribution were assessed by dual-energy X-ray absorptiometry and computed tomography while 25(OH)D levels were measured with an automated assay.

RESULTS:
The 1-year intervention resulted in a 26% increase in circulating 25(OH)D (from 48±2 nmol/l or 19±0.8 ng/ml (±s.e.m.) to 58±2 nmol/l or 23±0.8 ng/ml, P<0.0001) along with a 26% decrease in visceral adiposity volume (from 1947±458 cm3 to 1459±532 cm3). One-year increases in 25(OH)D levels correlated inversely with changes in all adiposity indices, especially Δvisceral (r=-0.36, P<0.0005) and Δtotal abdominal (r=-0.37, P<0.0005) adipose tissue volumes.

CONCLUSIONS:
These results indicate that there is a linear increase in circulating 25(OH)D levels as a function of adiposity volume loss and therefore suggest a role of adiposity reduction in the management of obesity-associated vitamin D insufficiency.

PMID: 26095245


See also VitaminDWiki



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