Weight loss increased Vitamin D levels, which improved bones and decreased inflammation – Oct 2015

Clinical Nutrition, Volume 34, Issue 5, October 2015, Pages 1010–1017, doi:10.1016/j.clnu.2014.11.004
Idoia Ibero-Baraibara, , Santiago Navas-Carreteroa, b, , Itziar Abetec, , J.A. Martineza, b, jalfmtz@unav.es , M.A. Zuleta, b,

The aim of this study is to further clarify the role of plasma 25(OH)D concentration after a weight-lowering nutritional intervention on body composition, blood pressure and inflammatory biomarkers in overweight/obese middle-aged subjects.

Methods: This longitudinal research encompassed a total of 50 subjects [57.26 (5.24) year], who were under a 15% energy restricted diet for 4 weeks. Anthropometric and body composition variables, blood routine, inflammatory markers as well as 25(OH)D were analysed.

Results: Circulating 25(OH)D levels [12.13(±17.61%)] increased while anthropometric, body composition, routine blood markers as well as the concentration of TNF-α, C-reactive protein and Lp-PLA2 were significantly reduced after the intervention.
Multiple linear regression analyses evidenced that Δ25(OH)D increase was linked to the

  • decrease in weight,
  • adiposity,
  • SBP and IL-6 levels.

Moreover, a relationship was found between Δ25(OH)D, Δfat mass (r = −0.405; p = 0.007), ΔSBP (r = −0.355; p = 0.021) and ΔIL-6 (r = −0.386; p = 0.014). On the other hand, a higher increase in 25(OH)D was accompanied by reductions in weight, BMI, SBP, IL-6 and an increase in bone mineral concentration (p < 0.05).
Interestingly, higher levels of 25(OH)D at the endpoint, showed a significantly higher decrease in weight, BMI and total fat mass.

Conclusions: The increase in plasma 25(OH)D level is linked with the decrease in SBP and adiposity in middle-aged subjects after a weight-loss intervention. Therefore, 25(OH)D assessment is a potential marker to be accounted in metabolic measures related to blood pressure, adiposity and inflammation in obesity management.

www.clinicaltrials.gov (NCT01596309)
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