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Second stroke 8X more likely if very low vitamin D – Oct 2016

Vitamin D status and the risk of recurrent stroke and mortality in ischemic stroke patients: Data from a 24-month follow-up study in China

The journal of nutrition, health & aging, pp 1–6, First Online: 13 October 2016
DOI: 10.1007/s12603-016-0821-z
H. QiuM. WangD. MiJizong ZhaoEmail authorW. TuQ. Liu


This was a 24 month followup of strokes in China

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In this study, we determined serum 25-hydroxyvitamin D 25(OH) D levels in serum, and investigated their associations with risk of recurrent stroke and mortality in a 24-month follow up study in Chinese patients with first-ever ischemic stroke.

In this preplanned post hoc analysis, serum levels of 25(OH) D and NIH stroke scale (NIHSS) were measured at the time of admission in a cohort of patients with ischemic stroke. We used logistic regression model to assess the relationship between 25(OH) D levels and risk recurrent stroke or mortality.

The follow-up rate was 98.2% in 220 stroke patients. Of 216 patients, 18.5% (95%CI: 13.3%–23.7%) patients had a stroke recurrence, and 30.1% (95% CI: 24.0%–36.2%) died. After adjustment for traditional risk factors, serum 25(OH) D levels were negatively associated with the risk of stroke recurrence (odds ratio [OR], 0.77; 95% confidence interval CI, 0.70–0.85; P< 0.001) and negatively associated with mortality during 24 months of follow-up (OR, 0.72; 95% CI, 0.64–0.80; P< 0.001). Compared with the first quartile of serum 25(OH) D levels, the ORs for stroke recurrence and mortality were as follows:

  • second quartile, 0.80 (95% CI, 0.63–0.93) and 0.77 (95% CI, 0.65–0.89);
  • third quartile, 0.42 (95% CI, 0.31–0.55) and 0.39 (95% CI, 0.30–0.52);
  • fourth quartile, 0.12 (95% CI, 0.07–0.19) and 0.10 (95% CI, 0.06–0.15), respectively.

Lower serum levels of 25(OH) D are independently associated with the stroke recurrence and mortality at 24 months in ischemic stroke patients.


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