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Restless legs syndrome 3X more likely during pregnancy (low vitamin D) – Oct 2015

Restless legs syndrome and pregnancy:
prevalence, possible pathophysiological mechanisms and treatment

Acta Neurologica Scandinavica, online 19 OCT 2015, DOI: 10.1111/ane.12520
R. Gupta 1, M. Dhyani 1, T. Kendzerska 2, S. R. Pandi-Perumal 3, A. S. BaHammam 4,5, P. Srivanitchapoom 6,7, S. Pandey 8 and M. Hallett 6

Restless legs syndrome (RLS) is a common sleep disorder that may be associated with pregnancy. Studies have found that the prevalence of RLS among pregnant women ranged from 10 to 34%. Typically, there is complete remission of symptoms soon after parturition; however, in some patients, they may continue postpartum.
RLS has been shown to be associated with a number of complications in pregnancy including

  • preeclampsia and
  • increased incidence of Cesarean sections.

Although multiple hypotheses have been proposed to explain this association, each individual hypothesis cannot completely explain the whole pathogenesis. Present understanding suggests that a

  • strong family history,
  • low serum iron and ferritin level, and
  • high estrogen level during pregnancy might play important roles.
  • Vitamin D deficiency and calcium metabolism may also play a role.

Medical treatment of RLS during pregnancy is difficult and challenging considering the risks to mother and fetus. However, in some cases, the disease may be severe enough to require treatment.

Publisher rents PDF for $6
The study says
Pregnant women with RLS reported more complications related to pregnancy and labor such as

  • threatened abortion,
  • premature labor,
  • difficult delivery, and
  • intrauterine growth retardation;
        however, the results were only marginally significant

Also – increased risk of preeclampsia in RLS pregnant women


Note: Iron, Magnesium, and Vitamin D each reduce RLS

See also VitaminDWiki

Pages listed in BOTH of the categories Iron and Pregnancy

See also web

Attached files

ID Name Comment Uploaded Size Downloads
6071 RLS pregnancy Sept 2015.pdf PDF 2015 admin 21 Oct, 2015 01:18 386.81 Kb 368
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