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Preventing a COVID-19 pandemic with Vitamin D – Grant April 2020

Re: Preventing a covid-19 pandemic:
Can vitamin D supplementation reduce the spread of COVID-19?
Try first with health care workers and first responders.

01 April 2020, William B. Grant, Research, Sunlight, Nutrition and Health Research Center
PO Box 641603, San Francisco, CA 94164-1603, @wbgrant2

VitaminDWiki

There are better ways to prevent the spread

The best way to reduce the spread of COVID-19 is to massively apply Vitamin D to the hotspots
The increased herd immunity will decrease the the number of individuals to which the virus can spread.
Removing the fuel will make a fire go out.
 
Outbreaks include
Senior home residents
Sailors on Navy Ships
Prisoners
Patients of psych wards
Homeless
Slums
Local Hotspots
 
Should also provide Vitamin D "insurance" to people who contact many others
Hospital staff
Politicians
Celebrities
 
Should also provide Vitamin D "insurance" to essential workers
Grocery clerks
Amazon distribution workers
WalMart employees
Truckers
 
Social distancing and masks just flatten the curve
Vitamin D should actually reduce the total number who will ever get symptoms or go into the hospital


25 most-recent changes to VIRUS pages (Coronavirus)

Id Page Hits Last modification Creator Categories
11728 COVID-19 treated by Vitamin D - studies, reports, videos 11618
01 Oct, 2020 20:13
admin Virus
11978 Sleep Apena patents are 5X more likely to have a COVID-19 infection requiring hospitalization - Sept 28, 2020 63
29 Sep, 2020 20:32
admin Sleep
Virus
11977 COVID-19, flu, virus, Selenium, Vitamin D, Glutathione - Interview Sept 2020 75
29 Sep, 2020 12:43
admin Virus
11895 COVID-19 possible therapies: Vitamin D, Selenium, Zinc, Vitamin C, Potassium, Resveratrol , etc.– Aug 5, 2020 320
29 Sep, 2020 12:23
admin Virus
Zinc
Resveratrol
11887 Observations that Vitamin D, Zinc, and Selenium separately reduce COVID-19 – Aug 7, 2020 876
29 Sep, 2020 12:21
admin Virus
Zinc
11580 COVID-19 Coronavirus can most likely be fought by Vitamin D 257144
28 Sep, 2020 15:17
admin Virus
11976 Pascal's wager applied to Vitamin D 187
27 Sep, 2020 16:32
admin Virus
11975 100,000 dollar bet that Vitamin D is effective in reducing the severity of Covid-19 - Sept 23, 2020 305
26 Sep, 2020 21:46
admin Virus
11767 Low Vitamin D increased chance of COVID-19, unless supplement – May 13, 2020 1289
26 Sep, 2020 11:40
admin Virus
11974 Dr. Fauci takes 6,000 IU of Vitamin D daily – Sept 2020 772
25 Sep, 2020 18:08
admin Virus
11891 Nutrients which fight viruses and fortify the immune system 703
25 Sep, 2020 13:03
admin Immunity
Virus
11959 Admission to COVID-19 ICU 1.7X more likely to have less than 20 ng of vitamin D – Sept 2020 90
24 Sep, 2020 19:13
admin Virus
11971 COVID-19 3.2X more likely to be severe if vitamin D deficient (80 patients) – Sept 22, 2020 113
23 Sep, 2020 12:44
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11970 Vaccination increased risk of getting (previous) Coronavirus infection by 1.36 X – Dept. of Defense Oct 2019 122
23 Sep, 2020 11:22
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9689 Vitamin D Effective in Preventing Flu if not vaccinated - June 2018 1433
23 Sep, 2020 11:18
admin Virus
11942 Perhaps the influenza vaccine will increase the risk of COVID-19 (it did by 2X in 2009 Coronavirus pandemic) 395
23 Sep, 2020 11:16
admin Virus
11968 COVID-19 harms Mitochondria, Vitamin D normalizes Mitochondria, etc.- Sept 2020 111
21 Sep, 2020 17:24
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11967 Low vitamin D increases the risk of hepatitis, influenza, Covid-19, AIDS and other viral diseases – Sept 2020 142
21 Sep, 2020 13:20
admin HIV
Virus
7698 Hepatitis B virus and Vitamin D - many studies 8691
21 Sep, 2020 13:07
admin Liver
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11966 COVID-19 risk reduced 5X by glasses, face shield, or mask – Sept 16, 2020 135
21 Sep, 2020 00:57
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11958 Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020 444
20 Sep, 2020 16:20
admin Skin - Dark
Virus
11964 COVID-19 risk reduction trials: Vitamin D is best so far - Sept 19, 2020 110
20 Sep, 2020 16:13
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11965 Virtually no COVID-19 cases in countries having more than 30 ng of Vitamin D - Sept 17, 2020 553
20 Sep, 2020 16:12
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11963 Studies on Vitamin D and COVID-19 (11 categories) - Sept 20, 2020 303
20 Sep, 2020 11:20
admin Virus
11899 Another gene which limits Vitamin D is found to increase COViD-19 (Binding Protein in this case) Aug 8, 2020 251
17 Sep, 2020 12:47
admin Vit D Binding Protein
Virus

A single megadose of vitamin D results in good enough levels to fight COVID-19 in 3 days

Standard dosing (10,000 IU/day) takes ~3 months

In the Spring of 2020 VitaminDWiki is setting up experiments and Randomized Controlled Trials to test how well megadosing fights COVID-19


Dear Editor,

There is reasonable evidence that higher 25-hydroxyvitamin D [25(OH)D] concentrations reduce the risk of respiratory tract infections. A meta-analysis of vitamin D supplementation trials found an inverse relationship between vitamin D supplementation and incidence of acute respiratory tract infections, especially for those with 25(OH)D concentrations below 25 nmol/l [1]. Several mechanisms by which vitamin D reduces risk of respiratory tract infections have been identified. One is that cathelicidens and defensins are induced that have antimicrobial and antiendotoxin properties [2]. Another is that vitamin D reduces the production of pro-inflammatory cytokines and increases production of anti-inflammatory cytokines 2. The innate immune system often goes into overdrive during respiratory tract infections, resulting in the cytokine storm that can damage the lining of the lungs [3]. Serum 25(OH)D concentrations have been found to be inversely correlated with development of acute respiratory distress syndrome [4].

An article tying this and other information together suggests that raising serum 25(OH)D concentrations to 100 – 150 nmol/l should be able to reduce the risk of COVID-19 infection and death [5]. To reach those concentrations rapidly would take large doses of vitamin D for a week or two, followed by several thousand IU/d vitamin D for the duration of the COVID-19 pandemic. Such doses have been found not to have adverse health effects [6]. In addition, vitamin D reduces risk of many chronic diseases such as cancer and diabetes mellitus in secondary analyses of large clinical trials [7], and observational studies have found inverse correlations between serum 25(OH)D concentration and all-cause mortality rate up to 100 nmol/l [8].

No results of clinical trials regarding vitamin D supplementation for prevention or treatment of COVID-19 have been reported. Thus, an important question is whether making a public health announcement that taking enough vitamin D to raise serum 25(OH)D concentrations is a good idea. On the pro side, high-dose vitamin D supplementation and 25(OH)D concentrations have very few adverse side effects [6, 9]. It is also very inexpensive in markets that are not regulated, such as in the United States. Also, high 25(OH)D concentrations are associated with many health benefits [10] (see, also, information at vitaminDWiki.com and Grassrootshealth.net). On the anti side, physicians and health policy makers are reluctant to recommend health interventions that have not been rigorously tested and approved.

In my opinion, supplementation with substantial vitamin D doses is justified based on the enormous health and economic magnitude of the COVID-19 pandemic, the likely benefit in reducing risk of COVID-19 infection incidence and severity, and the preponderance of other health benefits from vitamin D supplementation and higher 25(OH)D concentrations with minimal adverse effects.

In terms of rolling out this recommendation, it is proposed that health care providers and first responders might try it first. Many of them lack adequate personal protective equipment and are contracting COVID-19 as a result. They have the training and motivation to lead the way in evaluating the benefit of vitamin D supplementation to help stem the COVID-19 pandemic. Measuring serum 25(OH)D concentrations at baseline and after supplementing for some time would be useful, especially in terms of evaluating the results in a field study rather than a randomized controlled trial [5].

References

  • 1. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;356:i6583. doi: 10.1136/bmj.i6583
  • 2. Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients 2020;12(1):E236. doi: 10.3390/nu12010236
  • 3. Guo XJ, Thomas PG. New fronts emerge in the influenza cytokine storm. Semin Immunopathol 2017;39(5):541-50. doi: 10.1007/s00281-017-0636-y
  • 4. Dancer RC, Parekh D, Lax S, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax 2015;70(7):617-24. doi: 10.1136/thoraxjnl-2014-206680
  • 5. Grant WB, Lahore H, McDonnell SL, et al. Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients 2020 doi: 10.20944/preprints202003.0235.v2 [published Online First: 30 March 2020]
  • 6. McCullough PJ, Lehrer DS, Amend J. Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. J Steroid Biochem Mol Biol 2019;189:228-39. doi: 10.1016/j.jsbmb.2018.12.010
  • 7. Grant WB, Boucher BJ. Why Secondary Analyses in Vitamin D Clinical Trials Are Important and How to Improve Vitamin D Clinical Trial Outcome Analyses-A Comment on "Extra-Skeletal Effects of Vitamin D, Nutrients 2019, 11, 1460". Nutrients 2019;11(9) doi: 10.3390/nu11092182
  • 8. Garland CF, Kim JJ, Mohr SB, et al. Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. Am J Public Health 2014;104(8):e43-50. doi: 10.2105/AJPH.2014.302034
  • 9. Grant WB, Karras SN, Bischoff-Ferrari HA, et al. Do studies reporting 'U'-shaped serum 25-hydroxyvitamin D-health outcome relationships reflect adverse effects? Dermatoendocrinol 2016;8(1):e1187349. doi: 10.1080/19381980.2016.1187349
  • 10. Charoenngam N, Shirvani A, Holick MF. Vitamin D for skeletal and non-skeletal health: What we should know. J Clin Orthop Trauma 2019;10(6):1082-93. doi: 10.1016/j.jcot.2019.07.004

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