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Preventing a COVID-19 pandemic with Vitamin D – Grant April 2020

Re: Preventing a covid-19 pandemic:
Can vitamin D supplementation reduce the spread of COVID-19?
Try first with health care workers and first responders.

01 April 2020, William B. Grant, Research, Sunlight, Nutrition and Health Research Center
PO Box 641603, San Francisco, CA 94164-1603, @wbgrant2

VitaminDWiki

There are better ways to prevent the spread

The best way to reduce the spread of COVID-19 is to massively apply Vitamin D to the hotspots
The increased herd immunity will decrease the the number of individuals to which the virus can spread.
Removing the fuel will make a fire go out.
 
Outbreaks include
Senior home residents
Sailors on Navy Ships
Prisoners
Patients of psych wards
Homeless
Slums
Local Hotspots
 
Should also provide Vitamin D "insurance" to people who contact many others
Hospital staff
Politicians
Celebrities
 
Should also provide Vitamin D "insurance" to essential workers
Grocery clerks
Amazon distribution workers
WalMart employees
Truckers
 
Social distancing and masks just flatten the curve
Vitamin D should actually reduce the total number who will ever get symptoms or go into the hospital


25 most-recent changes to VIRUS pages (Coronavirus)

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12024 Can vitamin D fight COVID-19 - interview of Dr. Matthews Oct 2020 262
29 Nov, 2020 21:55
admin Books, videos on Vitamin D
Virus
12092 Low Vitamin D may be associated with 90 percent of COVID-19 Deaths (comment on German study) – Nov 2020 117
29 Nov, 2020 16:29
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11728 COVID-19 treated by Vitamin D - studies, reports, videos 17339
29 Nov, 2020 15:40
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12096 COVID-19 and Vitamin D: Health Authorities do not understand risk-reward – Nov 2020 129
29 Nov, 2020 13:21
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12067 Governments and other groups are starting to use vitamin D to fight COVID-19 508
28 Nov, 2020 17:20
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12047 COVID-19 1.7X more likely to be severe if low Vitamin D - meta-analysis Oct 2020 137
28 Nov, 2020 13:51
admin Meta-analysis of Vitamin D
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12088 Vitamin D and COVID-19: Video and PDF by Dr. Grant (includes recommendations)- Nov 25, 2020 117
26 Nov, 2020 19:27
admin Books, videos on Vitamin D
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12090 COVID-19 male mortality increased 3.9 X if low vitamin D – observation Nov 25, 2020 85
26 Nov, 2020 13:12
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12073 Hospital COVID-19 observation: 7X more likely to live if more than 20 ng of vitamin D– Nov 19, 2020 562
26 Nov, 2020 11:15
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12086 COVID-19 – Putative Roles of Vitamin D – Nov 2020 167
25 Nov, 2020 19:39
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12079 Clinical trials are proving that Vitamin D fights COVID-19 in hospitals 444
25 Nov, 2020 00:38
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12083 Fight COVID-19 without drugs or vaccines, Vitamin D is the single most-studied way – Nov 2020 130
24 Nov, 2020 17:08
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11580 COVID-19 Coronavirus can most likely be fought by Vitamin D 265811
23 Nov, 2020 18:47
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12044 Residents of a Nursing Home who choose monthly Vitamin D had 4X fewer COVID-19 deaths – Nov 2, 2020 618
23 Nov, 2020 11:34
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11991 Children with low vitamin D far more likely to hospitalized with COVID-19 – Oct 2020 177
23 Nov, 2020 10:46
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12072 Severe COVID-19 not fought by vitamin D when given too late - RCT Nov 18, 2020 362
22 Nov, 2020 23:54
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11941 COVID-19 defeated by calcifediol form of Vitamin D in Spain - pilot RCT Aug 29, 2020 1288
22 Nov, 2020 22:34
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12037 Low Vitamin D associated 1.8X increased risk of COVID-19 death in hosptial – meta-analysis Nov 4, 2020 497
22 Nov, 2020 22:21
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12078 Vitamin D should fight COVID-19 (but Irish Consortium recommends only 1,000 IU) – Nov 21, 2020 166
21 Nov, 2020 20:11
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12057 How to identify and limit potential superspreaders 189
21 Nov, 2020 12:36
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12019 19X fewer COVID-19 infections if innate immune system activated – trial Oct 21, 2020 487
21 Nov, 2020 12:31
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8853 HPV 3X higher risk in women who are vitamin D deficient – Jan 2016 3100
20 Nov, 2020 12:52
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12074 New drug application to FDA for a probiotic which might treat COVID-19 – Nov 19, 2020 114
20 Nov, 2020 02:46
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12055 Many problems with Pfizer COVID-19 vaccine – Nov 9, 2020 234
18 Nov, 2020 10:52
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12050 Vitamin D fighting COVID-19 meets all Bradford Hill Criteria - Nov 2020 431
16 Nov, 2020 17:22
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A single megadose of vitamin D results in good enough levels to fight COVID-19 in 3 days

Standard dosing (10,000 IU/day) takes ~3 months


Dear Editor,

There is reasonable evidence that higher 25-hydroxyvitamin D [25(OH)D] concentrations reduce the risk of respiratory tract infections. A meta-analysis of vitamin D supplementation trials found an inverse relationship between vitamin D supplementation and incidence of acute respiratory tract infections, especially for those with 25(OH)D concentrations below 25 nmol/l [1]. Several mechanisms by which vitamin D reduces risk of respiratory tract infections have been identified. One is that cathelicidens and defensins are induced that have antimicrobial and antiendotoxin properties [2]. Another is that vitamin D reduces the production of pro-inflammatory cytokines and increases production of anti-inflammatory cytokines 2. The innate immune system often goes into overdrive during respiratory tract infections, resulting in the cytokine storm that can damage the lining of the lungs [3]. Serum 25(OH)D concentrations have been found to be inversely correlated with development of acute respiratory distress syndrome [4].

An article tying this and other information together suggests that raising serum 25(OH)D concentrations to 100 – 150 nmol/l should be able to reduce the risk of COVID-19 infection and death [5]. To reach those concentrations rapidly would take large doses of vitamin D for a week or two, followed by several thousand IU/d vitamin D for the duration of the COVID-19 pandemic. Such doses have been found not to have adverse health effects [6]. In addition, vitamin D reduces risk of many chronic diseases such as cancer and diabetes mellitus in secondary analyses of large clinical trials [7], and observational studies have found inverse correlations between serum 25(OH)D concentration and all-cause mortality rate up to 100 nmol/l [8].

No results of clinical trials regarding vitamin D supplementation for prevention or treatment of COVID-19 have been reported. Thus, an important question is whether making a public health announcement that taking enough vitamin D to raise serum 25(OH)D concentrations is a good idea. On the pro side, high-dose vitamin D supplementation and 25(OH)D concentrations have very few adverse side effects [6, 9]. It is also very inexpensive in markets that are not regulated, such as in the United States. Also, high 25(OH)D concentrations are associated with many health benefits [10] (see, also, information at vitaminDWiki.com and Grassrootshealth.net). On the anti side, physicians and health policy makers are reluctant to recommend health interventions that have not been rigorously tested and approved.

In my opinion, supplementation with substantial vitamin D doses is justified based on the enormous health and economic magnitude of the COVID-19 pandemic, the likely benefit in reducing risk of COVID-19 infection incidence and severity, and the preponderance of other health benefits from vitamin D supplementation and higher 25(OH)D concentrations with minimal adverse effects.

In terms of rolling out this recommendation, it is proposed that health care providers and first responders might try it first. Many of them lack adequate personal protective equipment and are contracting COVID-19 as a result. They have the training and motivation to lead the way in evaluating the benefit of vitamin D supplementation to help stem the COVID-19 pandemic. Measuring serum 25(OH)D concentrations at baseline and after supplementing for some time would be useful, especially in terms of evaluating the results in a field study rather than a randomized controlled trial [5].

References

  • 1. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;356:i6583. doi: 10.1136/bmj.i6583
  • 2. Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients 2020;12(1):E236. doi: 10.3390/nu12010236
  • 3. Guo XJ, Thomas PG. New fronts emerge in the influenza cytokine storm. Semin Immunopathol 2017;39(5):541-50. doi: 10.1007/s00281-017-0636-y
  • 4. Dancer RC, Parekh D, Lax S, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax 2015;70(7):617-24. doi: 10.1136/thoraxjnl-2014-206680
  • 5. Grant WB, Lahore H, McDonnell SL, et al. Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients 2020 doi: 10.20944/preprints202003.0235.v2 [published Online First: 30 March 2020]
  • 6. McCullough PJ, Lehrer DS, Amend J. Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. J Steroid Biochem Mol Biol 2019;189:228-39. doi: 10.1016/j.jsbmb.2018.12.010
  • 7. Grant WB, Boucher BJ. Why Secondary Analyses in Vitamin D Clinical Trials Are Important and How to Improve Vitamin D Clinical Trial Outcome Analyses-A Comment on "Extra-Skeletal Effects of Vitamin D, Nutrients 2019, 11, 1460". Nutrients 2019;11(9) doi: 10.3390/nu11092182
  • 8. Garland CF, Kim JJ, Mohr SB, et al. Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. Am J Public Health 2014;104(8):e43-50. doi: 10.2105/AJPH.2014.302034
  • 9. Grant WB, Karras SN, Bischoff-Ferrari HA, et al. Do studies reporting 'U'-shaped serum 25-hydroxyvitamin D-health outcome relationships reflect adverse effects? Dermatoendocrinol 2016;8(1):e1187349. doi: 10.1080/19381980.2016.1187349
  • 10. Charoenngam N, Shirvani A, Holick MF. Vitamin D for skeletal and non-skeletal health: What we should know. J Clin Orthop Trauma 2019;10(6):1082-93. doi: 10.1016/j.jcot.2019.07.004

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