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Preventing a COVID-19 pandemic with Vitamin D – Grant April 2020

Re: Preventing a covid-19 pandemic:
Can vitamin D supplementation reduce the spread of COVID-19?
Try first with health care workers and first responders.

01 April 2020, William B. Grant, Research, Sunlight, Nutrition and Health Research Center
PO Box 641603, San Francisco, CA 94164-1603, @wbgrant2

VitaminDWiki

There are better ways to prevent the spread

The best way to reduce the spread of COVID-19 is to massively apply Vitamin D to the hotspots
The increased herd immunity will decrease the the number of individuals to which the virus can spread.
Removing the fuel will make a fire go out.
 
Outbreaks include
Senior home residents
Sailors on Navy Ships
Prisoners
Patients of psych wards
Homeless
Slums
Local Hotspots
 
Should also provide Vitamin D "insurance" to people who contact many others
Hospital staff
Politicians
Celebrities
 
Should also provide Vitamin D "insurance" to essential workers
Grocery clerks
Amazon distribution workers
WalMart employees
Truckers
 
Social distancing and masks just flatten the curve
Vitamin D should actually reduce the total number who will ever get symptoms or go into the hospital


25 most-recent changes to VIRUS pages (Coronavirus)

Id Page Hits Last modification Creator Categories
11823 COVID-19 deaths strongly correlated with percent having less than 10 ng of Vitamin D in a country– July 1 2020 5
04 Jul, 2020 19:49
admin Virus
11728 COVID-19 treated by Vitamin D - studies, reports, videos 5585
04 Jul, 2020 19:12
admin Virus
11580 COVID-19 Coronavirus can most likely be fought by Vitamin D 242391
04 Jul, 2020 17:10
admin Virus
11736 COVID-19 was 19X more likely if low vitamin D (may be invalid data)– April 2020 5926
04 Jul, 2020 14:17
admin Virus
11826 Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020 8
04 Jul, 2020 14:00
admin Vitamin D Receptor
Virus
11825 Respiratory viral infection (RSV) and low vitamin D – July 2020 46
03 Jul, 2020 16:22
admin Breathing
Infant-Child
Virus
3780 Vitamin D can inhibit enveloped virus (e.g. Herpes, Zoster, Epstein, Hepatitis, Ebola) – March 2011 39372
03 Jul, 2020 15:22
admin Virus
11727 COVID-19 more frequent and deadly for those with dark skins (high risk of low vitamin D) 2167
01 Jul, 2020 20:50
admin Skin - Dark
Virus
11821 Nursing homes could reduce risk of COVID-19 with Vitamin D – June 30, 2020 59
01 Jul, 2020 16:05
admin Seniors
High Risk
Shut-in
Virus
11819 Hill's Criteria indicates that COVID-19 will be treated by Vitamin D - Annweiler June 8 2020 163
30 Jun, 2020 01:18
admin Virus
11805 Mild COVID-19 quickly treated by Zinc lozenges in 4 people – June 6, 2020 213
29 Jun, 2020 16:37
admin Immunity
Virus
Zinc
11817 High-altitude Cusco, Peru has far lower rate of COVID-19 than others (high UVB and Vitamin D) - June 2020 113
28 Jun, 2020 03:05
admin Virus
2253 Flu vaccine effectiveness and side effects 11011
27 Jun, 2020 17:57
admin Virus
11813 How We can fix this pandemic in a month (Vitamin D: 20K IU for 14 days) – June 22, 2020 453
23 Jun, 2020 01:11
admin Virus
11776 Vitamin D, Quercetin, and Estradiol all increase vitamin D in cells and increase genes which reduce COVID-19 – May 21... 584
22 Jun, 2020 01:30
admin Vitamin D Receptor
Virus
11807 Vitamin D deficiency and co-morbidities in COVID-19 patients – A fatal relationship – June 7, 2020 215
18 Jun, 2020 15:55
admin Virus
11799 Lockdown lunacy: The Thinking Person’s Guide – June 04, 2020 389
11 Jun, 2020 01:37
admin Virus
11798 The role of vitamin D in reducing risk of COVID-19: a brief survey of the literature - June 9, 2020 331
11 Jun, 2020 01:09
admin Virus
11797 Evidence Supports a Causal Model for Vitamin D in COVID-19 Outcomes – June 3, 2020 288
09 Jun, 2020 21:53
admin Virus
11749 COVID-19 association with Vitamin D also being explored by Hollis and Wagner - April 2020 878
09 Jun, 2020 09:14
admin Virus
11795 COVID-19 resulted in 3.7X decrease in Irish Very Low Weight Births (Vitamin D) - June 2020 207
08 Jun, 2020 00:47
admin Pregnancy
Virus
11794 Zinc, respiratory tract infections and COVID-19 – July 2020 472
07 Jun, 2020 21:16
admin Breathing
Virus
Zinc
9586 Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018 3532
07 Jun, 2020 20:31
admin Breathing
Immunity
Virus
Zinc
11766 Fight COVID-19 with Vitamin D, Vitamin C, Zinc, Selenium, Resveratrol, etc. - Sardi May 12, 2020 780
07 Jun, 2020 20:30
admin Virus
Zinc
Resveratrol
11791 Vitamin D nanoemulsion, with comments on COVID-19 – June 2, 2020 225
04 Jun, 2020 15:54
admin Forms of Vitamin D
Virus

A single megadose of vitamin D results in good enough levels to fight COVID-19 in 3 days

Standard dosing (10,000 IU/day) takes ~3 months

In the Spring of 2020 VitaminDWiki is setting up experiments and Randomized Controlled Trials to test how well megadosing fights COVID-19


Dear Editor,

There is reasonable evidence that higher 25-hydroxyvitamin D [25(OH)D] concentrations reduce the risk of respiratory tract infections. A meta-analysis of vitamin D supplementation trials found an inverse relationship between vitamin D supplementation and incidence of acute respiratory tract infections, especially for those with 25(OH)D concentrations below 25 nmol/l [1]. Several mechanisms by which vitamin D reduces risk of respiratory tract infections have been identified. One is that cathelicidens and defensins are induced that have antimicrobial and antiendotoxin properties [2]. Another is that vitamin D reduces the production of pro-inflammatory cytokines and increases production of anti-inflammatory cytokines 2. The innate immune system often goes into overdrive during respiratory tract infections, resulting in the cytokine storm that can damage the lining of the lungs [3]. Serum 25(OH)D concentrations have been found to be inversely correlated with development of acute respiratory distress syndrome [4].

An article tying this and other information together suggests that raising serum 25(OH)D concentrations to 100 – 150 nmol/l should be able to reduce the risk of COVID-19 infection and death [5]. To reach those concentrations rapidly would take large doses of vitamin D for a week or two, followed by several thousand IU/d vitamin D for the duration of the COVID-19 pandemic. Such doses have been found not to have adverse health effects [6]. In addition, vitamin D reduces risk of many chronic diseases such as cancer and diabetes mellitus in secondary analyses of large clinical trials [7], and observational studies have found inverse correlations between serum 25(OH)D concentration and all-cause mortality rate up to 100 nmol/l [8].

No results of clinical trials regarding vitamin D supplementation for prevention or treatment of COVID-19 have been reported. Thus, an important question is whether making a public health announcement that taking enough vitamin D to raise serum 25(OH)D concentrations is a good idea. On the pro side, high-dose vitamin D supplementation and 25(OH)D concentrations have very few adverse side effects [6, 9]. It is also very inexpensive in markets that are not regulated, such as in the United States. Also, high 25(OH)D concentrations are associated with many health benefits [10] (see, also, information at vitaminDWiki.com and Grassrootshealth.net). On the anti side, physicians and health policy makers are reluctant to recommend health interventions that have not been rigorously tested and approved.

In my opinion, supplementation with substantial vitamin D doses is justified based on the enormous health and economic magnitude of the COVID-19 pandemic, the likely benefit in reducing risk of COVID-19 infection incidence and severity, and the preponderance of other health benefits from vitamin D supplementation and higher 25(OH)D concentrations with minimal adverse effects.

In terms of rolling out this recommendation, it is proposed that health care providers and first responders might try it first. Many of them lack adequate personal protective equipment and are contracting COVID-19 as a result. They have the training and motivation to lead the way in evaluating the benefit of vitamin D supplementation to help stem the COVID-19 pandemic. Measuring serum 25(OH)D concentrations at baseline and after supplementing for some time would be useful, especially in terms of evaluating the results in a field study rather than a randomized controlled trial [5].

References

  • 1. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;356:i6583. doi: 10.1136/bmj.i6583
  • 2. Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients 2020;12(1):E236. doi: 10.3390/nu12010236
  • 3. Guo XJ, Thomas PG. New fronts emerge in the influenza cytokine storm. Semin Immunopathol 2017;39(5):541-50. doi: 10.1007/s00281-017-0636-y
  • 4. Dancer RC, Parekh D, Lax S, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax 2015;70(7):617-24. doi: 10.1136/thoraxjnl-2014-206680
  • 5. Grant WB, Lahore H, McDonnell SL, et al. Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients 2020 doi: 10.20944/preprints202003.0235.v2 [published Online First: 30 March 2020]
  • 6. McCullough PJ, Lehrer DS, Amend J. Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. J Steroid Biochem Mol Biol 2019;189:228-39. doi: 10.1016/j.jsbmb.2018.12.010
  • 7. Grant WB, Boucher BJ. Why Secondary Analyses in Vitamin D Clinical Trials Are Important and How to Improve Vitamin D Clinical Trial Outcome Analyses-A Comment on "Extra-Skeletal Effects of Vitamin D, Nutrients 2019, 11, 1460". Nutrients 2019;11(9) doi: 10.3390/nu11092182
  • 8. Garland CF, Kim JJ, Mohr SB, et al. Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. Am J Public Health 2014;104(8):e43-50. doi: 10.2105/AJPH.2014.302034
  • 9. Grant WB, Karras SN, Bischoff-Ferrari HA, et al. Do studies reporting 'U'-shaped serum 25-hydroxyvitamin D-health outcome relationships reflect adverse effects? Dermatoendocrinol 2016;8(1):e1187349. doi: 10.1080/19381980.2016.1187349
  • 10. Charoenngam N, Shirvani A, Holick MF. Vitamin D for skeletal and non-skeletal health: What we should know. J Clin Orthop Trauma 2019;10(6):1082-93. doi: 10.1016/j.jcot.2019.07.004

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