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Preventing a COVID-19 pandemic with Vitamin D – Grant April 2020

Re: Preventing a covid-19 pandemic:
Can vitamin D supplementation reduce the spread of COVID-19?
Try first with health care workers and first responders.

01 April 2020, William B. Grant, Research, Sunlight, Nutrition and Health Research Center
PO Box 641603, San Francisco, CA 94164-1603, @wbgrant2

VitaminDWiki

There are better ways to prevent the spread

The best way to reduce the spread of COVID-19 is to massively apply Vitamin D to the hotspots
The increased herd immunity will decrease the the number of individuals to which the virus can spread.
Removing the fuel will make a fire go out.
 
Outbreaks include
Senior home residents
Sailors on Navy Ships
Prisoners
Patients of psych wards
Homeless
Slums
Local Hotspots
 
Should also provide Vitamin D "insurance" to people who contact many others
Hospital staff
Politicians
Celebrities
 
Should also provide Vitamin D "insurance" to essential workers
Grocery clerks
Amazon distribution workers
WalMart employees
Truckers
 
Social distancing and masks just flatten the curve
Vitamin D should actually reduce the total number who will ever get symptoms or go into the hospital


25 most-recent changes to VIRUS pages (Coronavirus)

Id Page Hits Last modification Creator Categories
12013 COVID-19 associated with low Vitamin D in China in the Spring - Sept 2020 59
18 Oct, 2020 13:02
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12007 AI is examining 170,000 potential COVID-19 treatments, Vitamin D is one of only 6 found – Sept 4, 2020 474
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12010 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020 224
16 Oct, 2020 23:30
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12012 COVID-19 and Vitamin D - 14 studies as of Oct 16, 2020 100
16 Oct, 2020 16:33
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11728 COVID-19 treated by Vitamin D - studies, reports, videos 13123
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12009 COVID-19 fought by Vitamin D in 43 studies - Oct 15, 2020 178
15 Oct, 2020 16:10
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11795 COVID-19 resulted in 3.7X decrease in Irish Very Low Weight Births (Vitamin D) - June 2020 543
15 Oct, 2020 15:29
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3780 Vitamin D can inhibit enveloped virus (e.g. Herpes, Zoster, Epstein, Hepatitis, Ebola) – March 2011 41054
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5894 Vitamin D and the anti-viral state – March 2010 3515
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11681 Vitamin D supplementation could prevent and treat influenza, CORONAVIRUS, and pneumonia infections - March 2020 3903
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11749 COVID-19 association with Vitamin D also being explored by Hollis and Wagner - April 2020 1233
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11716 Global Push for RCTs in COVID-19 - April 4, 2020 616
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11707 Preventing a COVID-19 pandemic with Vitamin D – Grant April 2020 1494
15 Oct, 2020 10:15
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10823 How Vitamin D helps fight the cold, flu and other viruses - June 2019 482
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7470 Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009 4381
15 Oct, 2020 10:03
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11958 Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020 565
15 Oct, 2020 00:05
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11985 How Vitamin D Helps Fight COVID-19 - Grassroots Health Oct 2020 257
14 Oct, 2020 15:59
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11580 COVID-19 Coronavirus can most likely be fought by Vitamin D 259874
12 Oct, 2020 14:12
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12006 COVID-19 antibodies 2.6 X more likely if had symptoms and low vitamin D (UK hospital staff)– Oct 5 2020 173
11 Oct, 2020 19:32
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12005 Vaccines are plan A for COVID-19 Immunity (no plan B) - Sept 11, 2020 150
10 Oct, 2020 17:58
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12004 15 studies indicating that Vitamin D fights COVID-19 - Dr. Grimes Oct 9, 2020 1128
10 Oct, 2020 15:03
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12000 UK parliament members starting to be interested in Vitamin D for COVID-19 – Oct 10, 2020 229
10 Oct, 2020 13:01
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11998 Vitamin D could knock out COVID-19 in 3 months – Dr. Matthews interview Oct 2020 194
08 Oct, 2020 14:53
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11698 COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020 1070
07 Oct, 2020 15:02
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Diabetes
Hypertension
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11996 Diabetes increases COVID-19 severity and COVID-19 creates Diabetes - Oct 2020 99
07 Oct, 2020 14:58
admin Diabetes
Virus

A single megadose of vitamin D results in good enough levels to fight COVID-19 in 3 days

Standard dosing (10,000 IU/day) takes ~3 months


Dear Editor,

There is reasonable evidence that higher 25-hydroxyvitamin D [25(OH)D] concentrations reduce the risk of respiratory tract infections. A meta-analysis of vitamin D supplementation trials found an inverse relationship between vitamin D supplementation and incidence of acute respiratory tract infections, especially for those with 25(OH)D concentrations below 25 nmol/l [1]. Several mechanisms by which vitamin D reduces risk of respiratory tract infections have been identified. One is that cathelicidens and defensins are induced that have antimicrobial and antiendotoxin properties [2]. Another is that vitamin D reduces the production of pro-inflammatory cytokines and increases production of anti-inflammatory cytokines 2. The innate immune system often goes into overdrive during respiratory tract infections, resulting in the cytokine storm that can damage the lining of the lungs [3]. Serum 25(OH)D concentrations have been found to be inversely correlated with development of acute respiratory distress syndrome [4].

An article tying this and other information together suggests that raising serum 25(OH)D concentrations to 100 – 150 nmol/l should be able to reduce the risk of COVID-19 infection and death [5]. To reach those concentrations rapidly would take large doses of vitamin D for a week or two, followed by several thousand IU/d vitamin D for the duration of the COVID-19 pandemic. Such doses have been found not to have adverse health effects [6]. In addition, vitamin D reduces risk of many chronic diseases such as cancer and diabetes mellitus in secondary analyses of large clinical trials [7], and observational studies have found inverse correlations between serum 25(OH)D concentration and all-cause mortality rate up to 100 nmol/l [8].

No results of clinical trials regarding vitamin D supplementation for prevention or treatment of COVID-19 have been reported. Thus, an important question is whether making a public health announcement that taking enough vitamin D to raise serum 25(OH)D concentrations is a good idea. On the pro side, high-dose vitamin D supplementation and 25(OH)D concentrations have very few adverse side effects [6, 9]. It is also very inexpensive in markets that are not regulated, such as in the United States. Also, high 25(OH)D concentrations are associated with many health benefits [10] (see, also, information at vitaminDWiki.com and Grassrootshealth.net). On the anti side, physicians and health policy makers are reluctant to recommend health interventions that have not been rigorously tested and approved.

In my opinion, supplementation with substantial vitamin D doses is justified based on the enormous health and economic magnitude of the COVID-19 pandemic, the likely benefit in reducing risk of COVID-19 infection incidence and severity, and the preponderance of other health benefits from vitamin D supplementation and higher 25(OH)D concentrations with minimal adverse effects.

In terms of rolling out this recommendation, it is proposed that health care providers and first responders might try it first. Many of them lack adequate personal protective equipment and are contracting COVID-19 as a result. They have the training and motivation to lead the way in evaluating the benefit of vitamin D supplementation to help stem the COVID-19 pandemic. Measuring serum 25(OH)D concentrations at baseline and after supplementing for some time would be useful, especially in terms of evaluating the results in a field study rather than a randomized controlled trial [5].

References

  • 1. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;356:i6583. doi: 10.1136/bmj.i6583
  • 2. Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients 2020;12(1):E236. doi: 10.3390/nu12010236
  • 3. Guo XJ, Thomas PG. New fronts emerge in the influenza cytokine storm. Semin Immunopathol 2017;39(5):541-50. doi: 10.1007/s00281-017-0636-y
  • 4. Dancer RC, Parekh D, Lax S, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax 2015;70(7):617-24. doi: 10.1136/thoraxjnl-2014-206680
  • 5. Grant WB, Lahore H, McDonnell SL, et al. Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients 2020 doi: 10.20944/preprints202003.0235.v2 [published Online First: 30 March 2020]
  • 6. McCullough PJ, Lehrer DS, Amend J. Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. J Steroid Biochem Mol Biol 2019;189:228-39. doi: 10.1016/j.jsbmb.2018.12.010
  • 7. Grant WB, Boucher BJ. Why Secondary Analyses in Vitamin D Clinical Trials Are Important and How to Improve Vitamin D Clinical Trial Outcome Analyses-A Comment on "Extra-Skeletal Effects of Vitamin D, Nutrients 2019, 11, 1460". Nutrients 2019;11(9) doi: 10.3390/nu11092182
  • 8. Garland CF, Kim JJ, Mohr SB, et al. Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. Am J Public Health 2014;104(8):e43-50. doi: 10.2105/AJPH.2014.302034
  • 9. Grant WB, Karras SN, Bischoff-Ferrari HA, et al. Do studies reporting 'U'-shaped serum 25-hydroxyvitamin D-health outcome relationships reflect adverse effects? Dermatoendocrinol 2016;8(1):e1187349. doi: 10.1080/19381980.2016.1187349
  • 10. Charoenngam N, Shirvani A, Holick MF. Vitamin D for skeletal and non-skeletal health: What we should know. J Clin Orthop Trauma 2019;10(6):1082-93. doi: 10.1016/j.jcot.2019.07.004

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