Minerva Med. 2018 Apr;109(2):79-87. doi: 10.23736/S0026-4806.17.05447-7. Epub 2017 Nov 7.
Curic N1, Ilincic B1, Milic N2, Cabarkapa V1, Nikolic S1, Medic-Stojanoska M3, Pellicano R4, Abenavoli L5,6.
1 Center for Laboratory Medicine, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
2 Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
3 Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
4 Department of Gastro-Hepatology, Molinette Hospital, Turin, Italy.
5 Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia - l.abenavoli at unicz.it.
6 Department of Health Sciences, University "Magna Græcia", Catanzaro, Italy.
|Vitamin D:||80%||<20 ng/ml|
|Vitamin B12:||66%||< 221 pmol/L|
This is an association study.
Do not know if low Vitamin ==> Obesity or if Obesity ==> low vitamin
- B12 category listing has
33 items along with related searches
- Hypothesis – Vitamin B-12 deficiency is associated with Vitamin D deficiency
Overview Obesity and Vitamin D contains the following summary
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 126 trials for vitamin D intervention of obesity as of Dec 2017
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Those with darker skins were more likely to be obese Sept 2014
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
- Obesity category has
- Normal weight Obese (50 ng = 125 nanomole)
In obesity, low levels of vitamin D (VD) and vitamin B12 (VB12) may be the result of different pathophysiological mechanisms, but the possible association between them has not been defined yet. The aim of this cross-sectional analysis was to investigate the possible relationship between serum 25-hydroxyvitamin D (25(OH)D) and VB12 levels in middle aged women.
In 80 women, we indirectly evaluated body composition and body volumes [extracellular fluid volume (ECV) and total body water (TBW)] by anthropometric and bioelectrical impedance analysis. Vitamin D and VB12 status was assessed by laboratory measurement [serum 25(OH)D levels by electrochemiluminescent immunoassay; VB12 by chemiluminescent microparticle immunoassay].
Obese women were mostly VD deficient [25(OH)D below 50 nmol/L; 40/50, 80%]. Also, among obese we observed presence of VB12 deficiency [VB12 below 148 pmol/L; 13/50, 26%) and marginal depletion of VB12 level (marginal VB12 status 148-221 pmol/L; 20/50, 40%). All anthropometric indicators of obesity, ECV and TBW were significantly associated with both, 25(OH)D and VB12 (P<0.001) levels. In univariate regression analysis serum level of 25(OH)D was significantly associated with VB12 levels (R2=0.170, P<0.001). In regression models, 25(OH)D was significantly associated with VB12 level, independently of fat mass and extracellular fluid volume.
Obesity may negatively affect VB12 level, indirectly, by reducing 25(OH)D level in middle aged women.
PMID: 29115801 DOI: 10.23736/S0026-4806.17.05447-7