Loading...
 
Translate Register Log In Login with facebookLogin and Register

Obese women deficient in both Vitamin D and Vitamin B12 – March 2018

The relationship between the vitamin serum 25(OH)D and the B12 concentrations in obese women.

Minerva Med. 2018 Apr;109(2):79-87. doi: 10.23736/S0026-4806.17.05447-7. Epub 2017 Nov 7.
Curic N1, Ilincic B1, Milic N2, Cabarkapa V1, Nikolic S1, Medic-Stojanoska M3, Pellicano R4, Abenavoli L5,6.
1 Center for Laboratory Medicine, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
2 Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
3 Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
4 Department of Gastro-Hepatology, Molinette Hospital, Turin, Italy.
5 Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia - l.abenavoli at unicz.it.
6 Department of Health Sciences, University "Magna Græcia", Catanzaro, Italy.

VitaminDWiki

Obese women

Vitamin D: 80% <20 ng/ml
Vitamin B12: 66% < 221 pmol/L

This is an association study.
Do not know if low Vitamin ==> Obesity or if Obesity ==> low vitamin


Overview Obesity and Vitamin D contains the following summary

Image

  • Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study


BACKGROUND:
In obesity, low levels of vitamin D (VD) and vitamin B12 (VB12) may be the result of different pathophysiological mechanisms, but the possible association between them has not been defined yet. The aim of this cross-sectional analysis was to investigate the possible relationship between serum 25-hydroxyvitamin D (25(OH)D) and VB12 levels in middle aged women.

METHODS:
In 80 women, we indirectly evaluated body composition and body volumes [extracellular fluid volume (ECV) and total body water (TBW)] by anthropometric and bioelectrical impedance analysis. Vitamin D and VB12 status was assessed by laboratory measurement [serum 25(OH)D levels by electrochemiluminescent immunoassay; VB12 by chemiluminescent microparticle immunoassay].

RESULTS:
Obese women were mostly VD deficient [25(OH)D below 50 nmol/L; 40/50, 80%]. Also, among obese we observed presence of VB12 deficiency [VB12 below 148 pmol/L; 13/50, 26%) and marginal depletion of VB12 level (marginal VB12 status 148-221 pmol/L; 20/50, 40%). All anthropometric indicators of obesity, ECV and TBW were significantly associated with both, 25(OH)D and VB12 (P<0.001) levels. In univariate regression analysis serum level of 25(OH)D was significantly associated with VB12 levels (R2=0.170, P<0.001). In regression models, 25(OH)D was significantly associated with VB12 level, independently of fat mass and extracellular fluid volume.

CONCLUSIONS:
Obesity may negatively affect VB12 level, indirectly, by reducing 25(OH)D level in middle aged women.

PMID: 29115801 DOI: 10.23736/S0026-4806.17.05447-7

Created by admin. Last Modification: Friday March 30, 2018 15:57:58 GMT-0000 by admin. (Version 3)
See any problem with this page? Report it (FINALLY WORKS)