Melanoma survival doubled with Vitamin D binding protein polymorphism – Nov 2015

Genetic Variants in the Vitamin D Pathway Genes VDBP and RXRA Modulate Cutaneous Melanoma Disease-Specific Survival.

Pigment Cell Melanoma Res. 2015 Nov 17. doi: 10.1111/pcmr.12437. [Epub ahead of print]
Yin J1,2,3,4, Liu H2,3, Yi X2,3, Wu W5, Amos CI6, Fang S7, Lee JE7, Han J5,8, Wei Q2,3.
1Department of Epidemiology, School of Public Health, Medical College of Soochow University, 199 Ren-ai Road Industrial Park District, Suzhou, China.
2Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA.
3 Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
4 Department of Epidemiology and Biostatistics and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
5 Department of Epidemiology, Fairbanks School of Public Health, Indiana University, and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, 46202, USA.
6 Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA.
7 Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030, USA.
8 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.

Single nucleotide polymorphisms (SNPs) in the vitamin D pathway genes have been implicated in cutaneous melanoma (CM) risk, but their role in CM disease-specific survival (DSS) remains obscure.
We comprehensively analyzed the prognostic roles of 2,669 common SNPs in the vitamin D pathway genes using data from a published genome-wide association study (GWAS) at The University of Texas M.D. Anderson Cancer Center (MDACC) and then validated the SNPs of interest in another GWAS from the Nurses' Health Study and Health Professionals Follow-up Study. Among the 2,669 SNPs, 203 were significantly associated with DSS in MDACC dataset (P<0.05 and false positive report probability<0.2), of which 18 were the tag SNPs. In the replication, 2 of these 18 SNPs showed nominal significance:

the VDBP rs12512631 T>C was associated with a better DSS [combined hazards ratio (HR)=0.66]; and the same for
RXRA rs7850212 C>A (combined HR=0.38),

which were further confirmed by the Fine and Gray competing risks regression model. Further bioinformatics analyses indicated that these loci may modulate corresponding gene methylation status.
This article is protected by copyright. All rights reserved.

PMID: 26575331

20 most visited VitaminDWiki VDBP pages

Id	Page	Hits	Last modification	Creator	Categories
3439	Genetics	109920	03 Dec, 2024 19:58	ricks99	Genetics Vitamin D Receptor Vit D Binding Protein Category
7403	Health problems that run in families are often associated with low vitamin D	39084	20 Aug, 2023 15:34	admin	Health Genetics Top news Vitamin D Receptor Vit D Binding Protein
6867	Vitamin D Binding Protein	37310	19 Nov, 2024 02:42	admin	Vit D Binding Protein Category Associations
8113	Vitamin D - Binding Protein, Receptor, enzymes and health benefits - review Jan 2016	22352	15 Apr, 2017 20:19	admin	Genetics Vitamin D Receptor Vit D Binding Protein
3335	Vitamin D levels are strongly associated with genes: overview of twin studies – Nov 2012	21828	17 Dec, 2019 12:45	admin	Genetics Vitamin D Receptor Vit D Binding Protein CYP27B1
10726	Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018	21069	25 Jun, 2021 11:15	admin	Genetics Top news Cognitive Vitamin D Receptor Vit D Binding Protein
6306	Growth Hormone problem (Acromegaly) more likely if vitamin D gene problems	20779	10 Dec, 2019 13:18	admin	Vitamin D Receptor Vit D Binding Protein
3881	Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc.	19426	28 Nov, 2014 19:11	admin	Deficiency of Vitamin D How much Vitamin D Kidney Vitamin D and Magnesium Genetics Top news Vitamin D Receptor Vit D Binding Protein
10601	Vitamin D Nutrigenomics - High, Medium, and Low Responders - March 2019	19185	07 Dec, 2022 18:33	admin	Genetics Predict Vitamin D Vitamin D Receptor Vit D Binding Protein
10488	Rheumatoid Arthritis synovial fluid has lower levels Vitamin D binding protein, 3-epi – Jan 2019	18473	14 Feb, 2019 02:46	admin	Rheumatoid Arthritis Vit D Binding Protein
6835	Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015	16734	30 Jul, 2023 17:47	admin	Multiple Sclerosis Genetics Top news Vit D Binding Protein
11237	Topical Vitamin D provides more benefits than oral sometimes - many studies	14682	26 Jan, 2024 17:03	admin	Forms of Vitamin D Treatment by Vitamin D Gut Top news Skin Vit D Binding Protein
5556	4700 IU of vitamin D needed by most seniors – an equation -July 2014	14251	13 Jul, 2024 15:46	admin	How much Vitamin D Seniors Predict Vitamin D Vit D Binding Protein
3383	Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues	13508	26 Jul, 2021 09:51	admin	Cardiovascular Vitamin D and Magnesium Vitamin D and Omega-3 Vit D Binding Protein
4011	Common Vitamin D gene variants and resulting diseases – Jan 2013	13433	16 Oct, 2017 11:16	admin	Genetics Top news Vit D Binding Protein
6158	Multiple Sclerosis is associated with about 1.5 X more Vitamin D Binding Protein – Jan 2015	12438	25 Feb, 2015 22:44	admin	Multiple Sclerosis Vit D Binding Protein
6881	Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015	11929	18 Sep, 2018 09:10	admin	Cognitive Vitamin D Receptor Vit D Binding Protein
11571	Sweat types, folate, binding protein, lighter skin in females and Vitamin D – Jan 2020	11339	19 Jan, 2020 13:51	admin	Skin - Dark About D - more info. Vit D Binding Protein
6797	Bioavailable Vitamin D is the same blacks and whites, but measured vit D is not – Oct 2014	11101	31 Dec, 2015 13:53	admin	Skin - Dark Vit D Binding Protein
7270	Vitamin D dose size needed – VitD testing tells only a portion of the story – Jan 2016	10850	12 Nov, 2016 08:22	admin	How much Vitamin D Genetics Vitamin D Receptor Vit D Binding Protein