Epilepsy & Behavior; Available online 11 April 2012
Brief Communication http://dx.doi.org/10.1016/j.yebeh.2012.03.011,
András Hollóa, Zsófia Clemensb clemenszsofia at gmail.com, Anita Kamondib, Péter Lakatosc, Anna Sz?csb
a National Institute for Medical Rehabilitation, H-1121 Budapest, Szanatórium u. 19, Hungary
b National Institute of Neuroscience, H-1145 Budapest, Amerikai út 57, Hungary
c Semmelweis University, 1st Department of Internal Medicine, H-1083 Budapest, Korányi Sándor u. 2/a, Hungary
There is growing interest concerning the role of vitamin D in various medical conditions such as diabetes and oncological, cardiovascular and central nervous system disorders. Although vitamin D deficiency is known to be highly prevalent among epilepsy patients, only a single study, published nearly forty years ago, assessed the effect of vitamin D on seizure control. Here, we measured serum 25-hydroxy-vitamin D (25(OH)D) levels and normalized it by administration of vitamin D3 in 13 patients with pharmacoresistant epilepsy. To see if vitamin D3 has an impact on seizure frequency, we compared seizure numbers during a 90-day period before and after treatment onset. We found that seizure numbers significantly decreased upon vitamin D3 supplementation. Median seizure reduction was 40%. We conclude that the normalization of serum vitamin 25(OH)D level has an anticonvulsant effect.
Normalizing probably means vitamin D levels > 30 nanogram, but it might mean > 20 nanogram.
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The causes of epilepsy can be divided into two groups: brain injuries and chemical imbalances in the brain.
Anything that injures the brain can lead to seizures. But in over half the cases no cause can be identified.
- See also Brain trauma and low vitamin D
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