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Endometriosis: 2.7 X more likely if with low vitamin D (trend of 9 studies)– meta-analysis May 2020

Vitamin D status in endometriosis: a systematic review and meta-analysis

Archives of Gynecology and Obstetrics (2020) https://doi.org/10.1007/s00404-020-05576-5
Yichao Qiu, Shuang Yuan & Hongjing Wang


Endometriosis treated, and perhaps prevented, by vitamin D

Women category starts with the following

No consensus exists on the relationship between vitamin D status and endometriosis. The chief aim of our study was to evaluate the association between serum vitamin D levels and endometriosis.

We searched for MEDLINE, EMBASE, and China National Knowledge Infrastructure (CNKI) databases for studies elucidated the circulating vitamin D levels in endometriosis. The standardized mean differences (SMDs) or odds ratios (ORs) with their 95% confidence interval (CIs) were calculated to evaluate the association between vitamin D levels and endometriosis.

Nine studies were included in this meta-analysis. The pooled results indicated that women with endometriosis had lower vitamin D status than that in controls (SMD − 0.97 ng/mL, 95% CI − 1.80 to − 0.14; p = 0.02), and vitamin D status had a negative correlation with the severity of the disease (stage III–IV vs stage I–II: SMD − 1.33 ng/mL, 95% CI − 2.54 to − 0.12; p = 0.03).

Although it was not statistically significantly different, hypovitaminosis D had a tendency to be associated with endometriosis (OR 2.77, 95% CI 0.85–6.08, p = 0.10). Heterogeneity was high among included studies. Subgroup analyses revealed that women with no hormone use had lower vitamin D status when compared with controls (SMD − 1.38 ng/mL, 95% CI − 2.59 to − 0.18; p = 0.02). For studies which sample size < 100, serum vitamin D levels were significantly lower in patients than that in controls (SMD − 0.65 ng/mL, 95% CI − 1.19 to − 0.11; p = 0.02).

Women with endometriosis had lower vitamin D status when compared with controls, and a negative relationship between vitamin D levels and severity of endometriosis was observed. In addition, hypovitaminosis D was a potential risk factor for endometriosis.

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