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Elderly women with vitamin D under 20 ng had more medical comorbidities – Jan 2010

Vitamin D insufficiency and health outcomes over 5 y in older women.

Am J Clin Nutr. 2010 Jan;91(1):82-9. Epub 2009 Nov 11.
Bolland MJ, Bacon CJ, Horne AM, Mason BH, Ames RW, Wang TK, Grey AB, Gamble GD, Reid IR.
Department of Medicine, University of Auckland, Auckland, New Zealand. m.bolland at auckland.ac.nz

BACKGROUND: Vitamin D insufficiency was shown to be associated with adverse musculoskeletal and nonskeletal outcomes in numerous observational studies. However, some studies did not control for confounding factors such as age or seasonal variation of 25-hydroxyvitamin D 25(OH)D.

OBJECTIVE: We sought to determine the effect of vitamin D status on health outcomes.

DESIGN: Healthy community-dwelling women (n = 1471) with a mean age of 74 y were followed in a 5-y trial of calcium supplementation. 25(OH)D was measured at baseline in all women. Skeletal and nonskeletal outcomes were evaluated according to seasonally adjusted vitamin D status at baseline.

RESULTS: Fifty percent of women had a seasonally adjusted 25(OH)D concentration <50 nmol/L. These women were significantly older, heavier, and less physically active and had more comorbidities than women with a seasonally adjusted 25(OH)D concentration > or =50 nmol/L.

Women with a seasonally adjusted 25(OH)D concentration <50 nmol/L had an increased incidence of stroke and cardiovascular events that did not persist after adjustment for between-group differences in age or comorbidities.

Women with a seasonally adjusted 25(OH)D concentration <50 nmol/L were not at increased risk of adverse consequences for any musculoskeletal outcome, including fracture, falls, bone density, or grip strength or any nonskeletal outcomes, including death, myocardial infarction, cancer, heart failure, diabetes, or adverse changes in blood pressure, weight, body composition, cholesterol, or glucose.

CONCLUSIONS: Vitamin D insufficiency is more common in older, frailer women. Community-dwelling older women with a seasonally adjusted 25(OH)D concentration <50 nmol/L were not at risk of adverse outcomes over 5 y after control for comorbidities. Randomized placebo-controlled trials are needed to determine whether vitamin D supplementation in individuals with vitamin D insufficiency influences health outcomes. This trial was registered at www.anzctr.org.au as ACTRN 012605000242628. PMID: 19906799

Comment Comorbidity Refers to the existence of two or more diseases or conditions in the same individual at the same time. Indicates a medical condition in a patient that causes, is caused by, or is otherwise related to another condition in the same patient Example: Obesity has comorbidity of diabetes, so this study would have ignored this disease pair with vitamin D deficiency

See also VitaminDWiki