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Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016

Increases in pre-hospitalization serum 25(OH)D concentrations are associated with improved 30-day mortality after hospital admission: A cohort study.

Clin Nutr. 2016 Apr;35(2):514-21. doi: 10.1016/j.clnu.2015.03.020. Epub 2015 Apr 14.

  • This study says this might be just an association, and does not prove causation
  • However, many of the studies below indicate higher vitamin D levels are associated with lower hospitalization mortality
  • Note: I keep 400,000 IU Vitamin D in my car in case of an emergency - Henry Lahore

See also VitaminDWiki

Publisher wants $36 for the PDF

Amrein K 1, Litonjua AA 2, Moromizato T 3, Quraishi SA 4, Gibbons FK 5, Pieber TR 1, Camargo CA Jr 6, Giovannucci E 7, Christopher KB 8.
1Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Austria.
2Channing Division of Network Medicine and Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
3Department of Medicine, Okinawa Hokubu Prefectural Hospital, Okinawa, Japan.
4Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
5Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
6Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.
7Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA.
8The Nathan E. Hellman Memorial Laboratory, Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. kbchristopher at partners.org.

CONTEXT: Pre-hospital vitamin D status may be a modifiable risk factor for all-cause mortality among hospitalized patients.

OBJECTIVE: To examine the association between increases in serum 25-hydroxyvitamin D 25(OH)D levels during the year before hospitalization and risk of 30-day all-cause mortality after hospital admission.

DESIGN: Retrospective cohort study.

SETTING: Two Boston teaching hospitals.

PATIENTS OR OTHER PARTICIPANTS: We studied 4344 adults hospitalized between 1993 and 2011 who had serum 25(OH)D concentrations measured at least twice within 7-365 days before the index hospitalization.


MAIN OUTCOME MEASURE(S): The exposure of interest was change in pre-hospital serum 25(OH)D concentrations. The main outcome was 30-day all-cause mortality. We used mixed-effects logistic regression to describe how 30-day mortality differed with changes in pre-hospital 25(OH)D concentrations. Additionally, the odds of 30-day mortality in patients with pre-hospital 25(OH)D increases of =10 ng/mL was compared to that of patients with increases of <10 ng/mL.

RESULTS: In a mixed-effect logistic regression model adjusted for age, gender, race, type (medical/surgical), Deyo-Charlson Index, creatinine and hematocrit, 30-day all-cause mortality rate was 8% (95%CI: 1-15) lower for each 10 ng/mL increase in pre-hospital 25(OH)D (P = 0.025) compared with the 30-day all-cause mortality rate in the entire cohort. In an adjusted logistic regression model, absolute changes of =10 ng/mL in patients with initial 25(OH)D concentrations < 20 ng/mL (n = 1944) decreased the odds of 30-day all-cause mortality by 48% (adjusted OR 0.52; 95%CI 0.30-0.93; P = 0.026) compared to patients with changes of <10 ng/mL.

CONCLUSIONS: In patients with initial 25(OH)D < 20 ng/mL, subsequent improvements in vitamin D status before hospitalization are associated with decreased odds of 30-day all-cause mortality after hospital admission. A causal relation may not be inferred from this observational study.

PMID: 25935851 DOI: 10.1016/j.clnu.2015.03.020

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