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COPD quality of life improved by 400,000 IU Vitamin D loading dose – RCT July 2019

Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial

International Journal of Chronic Obstructive Pulmonary Disease Volume 2019:14 Pages 1495—1501, https://doi.org/10.2147/COPD.S207400


COPD fought by Vitamin D - many studies has the following

AND includes the following sections
50,000 IU weekly - 6X more likely to improve breathing - 2014
50,000 IU helped COPD in many ways - Jan 2015
COPD has become the 3rd largest global cause of disability: ages 50-69
Loading Dose

  • Overview Loading of vitamin D
    • Loading may be done as quickly as a single day, to as slowly as 3 months.
    • It appears that spreading the loading dose over 4-20 days is a good compromise

A CAT (COPD Assesment Test) score - from the web (not the one they used)

 Download the PDF from VitaminDWiki
COPD Assesment Test improved signifiantly after 2 month loading dose
and doubled that improvement after maintenance dosing of 6 months



Ali Alavi Foumani,1 Mojtaba Mehrdad,1,2 Alireza Jafarinezhad,1 Khadijeh Nokani,3 Alireza Jafari1

  • 1 Inflammatory Lung Diseases Research Center, Dept of Internal Medicine, Razi Hospital, School of Medicine, Guilan U. of Medical Sciences, Rasht, Iran;
  • 2 Razi Clinical Research Development Center, Guilan University of Medical Sciences, Rasht, Iran;
  • 3 Student Research Committee, Department of Internal Medicine, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran

COPD is an irreversible chronic illness with airflow limitation. The aim of the current study was to assess the role of vitamin D3 on quality of life and pulmonary function in patients with COPD. A randomized, double-blinded clinical trial was conducted in 63 patients with COPD. Patients were placed into intervention and placebo groups. Each individual in the intervention group took 50,000 IU vitamin D3 once a week for 8 weeks and then once a month for 4 months. There was no significant difference among FEV1, FEV1/FVC, and number of exacerbations in patients with COPD (P>0.05). In the intervention group, a significant difference was observed in quality of life at 2 months (P<0.001) and 6 months (P<0.001). In addition, qualitative analysis showed that the status of exacerbation had not got worse six months after initiation in the intervention group. The current study shows that consumption of 50,000 IU vitamin D3, as a convenient supplementation in a daily diet, is able to increase quality of life in patients with COPD.

Created by admin. Last Modification: Sunday October 6, 2019 23:21:22 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
12287 CAT Score.jpg admin 08 Jul, 2019 123.55 Kb 1002
12286 COPD CAT.jpg admin 08 Jul, 2019 66.32 Kb 875
12285 COPD 6 months.jpg admin 08 Jul, 2019 105.41 Kb 857
12284 COPD QOL 400,000 loading.pdf admin 08 Jul, 2019 271.67 Kb 661