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COPD treated by Vitamin D – meta-analysis March 2022


Effects of Vitamin D on Respiratory Function and Immune Status for Patients with Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review and Meta-Analysis

Computational and Mathematical Methods in Medicine 2022 https://doi.org/10.1155/2022/2910782
Huan Yang ,1 Deyang Sun ,1 Fengqing Wu,2 Xiao Xu,2 Xi Liu,2 Zhen Wang ,3 and Linshui Zhou 3

Even with huge differences in dose size, type, and time COPD was, in net, still helped
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Background. Many studies have demonstrated that vitamin D has clinical benefits when used to treat patients with chronic obstructive pulmonary disease (COPD). However, most of these studies have insufficient samples or inconsistent results. The aim of this meta-analysis was to evaluate the effects of vitamin D therapy in patients with COPD.

Methods. We performed a comprehensive retrieval in the following electronic databases: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Chinese Scientific Journals Database (VIP). Two trained reviewers identified relevant studies, extracted data information, and then assessed the methodical quality by the Cochrane risk of bias assessment tool, independently. Then, the meta-analyses were conducted by RevMan 5.4, binary variables were represented by risks ratio (RR), and continuous variables were represented by mean difference (MD) or standardized mean difference (SMD) to assess the efficacy of vitamin D therapy in patients with COPD. Then, publication bias assessment was conducted by funnel plot analysis. Finally, the quality of evidence was assessed by the GRADE system.

Results. A total of 15 articles involving 1598 participants were included in this study. The overall results showed a statistical significance of vitamin D therapy in patients with COPD which can significantly improve forced expiratory volume in 1 second (FEV1) (MD: 5.69, 95% CI: 5.01-6.38,,) and FEV1/FVC (SMD:0.49, 95% CI: 0.39-0.60,,); and serum 25 (OH)D (SMD:1.21, 95% CI:1.07-1.34,,) also increase CD3+ Tcells (MD: 6.67, 95% CI: 5.34-8.00,,) and CD4+ T cells (MD: 6.00, 95% CI: 5.01-7.00,,); and T lymphocyte CD4+/CD8+ ratio (MD: 0.41, 95% CI: 0.20-0.61,,) obviously decrease CD8+ Tcells(SMD: -0.83, 95% CI: -1.05- -0.06,,), the times of acute exacerbation (RR: 0.40, 95% CI: 0.28-0.59,,), and COPD assessment test (CAT) score (MD: -3.77, 95% CI: -5.86 - -1.68,,).

Conclusions. Our analysis indicated that vitamin D used in patients with COPD could improve the lung function (FEV1 and FEV1/FVC), the serum 25(OH)D, CD3+ T cells, CD4 + T cells, and T lymphocyte CD4+/CD8+ ratio and reduce CD8+ T cells, acute exacerbation, and CAT scores.
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Note: Inhaled vitamin D was observed to also help COPD


VitaminDWiki Meta-analyses with COPD in title

This list is automatically updated

Items found: 6

VitaminDWiki pages with COPD in title

This list is automatically updated

Items found: 60
Title Modified
COPD fought by Vitamin D - many studies 23 Oct, 2023
The Sun is the best remedy for Your Lungs (Infection, Asthma and COPD) - video June 2022 27 Jun, 2022
COPD treated by Vitamin D – meta-analysis March 2022 12 Mar, 2022
Sarcopenia with obesity is more likely if dark skin, diabetes, OR COPD (all associated with low vitamin D) 16 Oct, 2021
Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT Feb 2021 28 Jun, 2021
High PTH plus low Vitamin D is not good (5X more likely for COPD to need hospital) – April 2021 25 Apr, 2021
Vitamin D is one of the alternate COPD therapies – March 2021 04 Apr, 2021
COPD trial to use 80,000 IU of vitamin D weekly – RCT 2021 19 Mar, 2020
Those with Asthma or COPD had half the response to Vitamin D – March 2020 19 Mar, 2020
COPD increases risk of bone fracture by 4.7 X (low vitamin D) – Dec 2019 08 Dec, 2019
Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019 26 Nov, 2019
Smoke Inflammation reduced by vitamin D (COPD in lab) – Sept 2019 06 Sep, 2019
COPD quality of life improved by 400,000 IU Vitamin D loading dose – RCT July 2019 08 Jul, 2019
COPD in Asians twice as likely if poor Vitamin D Binding Protein – meta-analysis May 2019 16 Jun, 2019
COPD flare-ups reduced 40 percent by Vitamin D in those who were deficient – May 2019 24 May, 2019
COPD results in bone loss and osteopenia, Vitamin D should reduce both – May 2019 16 May, 2019
COPD severity is associated with Vitamin D deficiency – meta-analyses 2015, 2019 17 Mar, 2019
COPD exacerbations 2X less often if low vitamin D then supplemented – meta-analysis Jan 2019 15 Jan, 2019
COPD 2.8 times more likely to be severe if low vitamin D – meta-analysis Oct 2016 13 Sep, 2018
COPD with obstruction: Death 1.7 X more likely with low vitamin D – Sept 2018 13 Sep, 2018
Worse breathing with COPD is related to lower Vitamin D – June 2018 01 Jul, 2018
Hypothesis – Use of anticoagulants with COPD lowers Vitamin K, which increases calcification – Nov 2017 25 Jan, 2018
COPD strongly associated with Vitamin D Binding Protein problems – meta-analysis Aug 2015 12 Jun, 2017
COPD ICU stay is 2.4 days longer if low vitamin D – Oct 2015 12 May, 2017
COPD and Vitamin D, concise (46 page) review – Dec 2016 07 Dec, 2016
COPD is associated with several other diseases (comorbidities) – July 2016 10 Oct, 2016
COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015 17 Sep, 2016
COPD, Osteoporosis, and low Vitamin D – Sept 2016 14 Sep, 2016
COPD strongly associated with Vitamin D receptor problems – meta-analysis Aug 2015 01 Dec, 2015
Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis Dec 2014 04 Nov, 2015
Danes opposed to Vitamin D fortification, will get more COPD, diabetes, depression, lupus, leg pain, etc – Oct 2015 31 Oct, 2015
Vitamin D loading dose then weekly 50,000 IU not help (COPD) if very deficient – Oct 2015 16 Oct, 2015
Asthma with COPD has lower vitamin D levels than asthma alone – Sept 2015 25 Sep, 2015
2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015 09 Sep, 2015
COPD 2.6X more likely if poor vitamin D binding protein – meta-analysis Dec 2014 27 Aug, 2015
COPD – almost all women in Bulgaria hospitalized with COPD had low vitamin D – June 2015 06 Jun, 2015
COPD reduced by vitamin D taken once every 60 days – RCT Dec 2014 03 Jun, 2015
COPD getting worse is associated with very low vitamin D – March 2015 03 Jun, 2015
Magnesium is associated with better quality of life in COPD, not Vitamin D – March 2015 13 May, 2015
COPD becoming suddenly worse is 30X more likely if low vitamin D – Dec 2014 13 Mar, 2015
Vitamin D treats COPD thru many pathways – March 2015 13 Mar, 2015
COPD and vitamin D in a vicious circle – April 2011 24 Jan, 2015
100000 IU vitamin D monthly helps COPD patients – 3 RCT 20 Jan, 2015
100000 IU vitamin D monthly helped COPD patients – 2011 and 2012 20 Jan, 2015
COPD 2.6X more likely if alteration in a Vitamin D gene (1F-1F ) – meta-analysis Dec 2014 18 Jan, 2015
Vitamin D Binding Protein, And Airflow In COPD - April 2012 21 Dec, 2014
COPD 2.6X more likely if poor vitamin D binding protein – Dec 2014 13 Dec, 2014
Genetic link found between vitamin D and COPD – June 2010 10 Dec, 2014
COPD helped by weekly 50,000 IU Vitamin D – Aug 2013 03 May, 2014
COPD lung volume reduction strongly associated with low vitamin D – March 2014 19 Mar, 2014
Asthma is strongly associated with low vitamin D (but not COPD) – meta-analysis Feb 2014 17 Mar, 2014
COPD 2X as likely if low vitamin D – review of 3 studies – March 2014 11 Mar, 2014
The worse the COPD the lower the levels of vitamin D – Aug 2012 28 Feb, 2014
Lung, lung cancer, asthma, COPD, and Vitamin D – July 2013 22 Feb, 2014
COPD reduce 2X if severely deficient and treated with 3,300 IU daily average of vitamin D – Jan 2012 15 Jun, 2013
COPD – Bone Metabolism – Osteoporosis – Vitamin D appear related – Mar 2011 02 May, 2013
COPD and Osteoporosis are related – vitamin D is one possible connection – 2013 02 May, 2013
COPD patients 4X more likely to have low Vitamin D – 2 articles in 2012 01 Nov, 2012
Less COPD if vitamin D more than 30 ng – Nov 2011 28 Sep, 2012
Vitamin D deficiency is highly prevalent in COPD - 2010 05 Nov, 2011

Created by admin. Last Modification: Saturday March 12, 2022 16:24:26 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
17193 COPD table2.jpg admin 12 Mar, 2022 242.63 Kb 175
17192 COPD Meta.pdf admin 12 Mar, 2022 842.01 Kb 152