Evidence from a Chinese Population Based Case-Control Study and Meta-Analysis of the Observational Studies.
PLoS One. 2013;8(1):e49312. doi: 10.1371/journal.pone.0049312. Epub 2013 Jan 30.
Chen P, Li M, Gu X, Liu Y, Li X, Li C, Wang Y, Xie D, Wang F, Yu C, Li J, Chen X, Chu R, Zhu J, Ou Z, Wang H.
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, P. R. China.
Experimental data suggest a protective effect of vitamin D on breast cancer; however, epidemiologic results remain inclusive. With a Chinese population-based case-control study and meta-analysis of the observational studies, we here systematically evaluated the association of blood 25(OH)D level and breast cancer risk. With 593 breast cancer cases and 580 cancer-free controls from Shanghai, China, we found that 80% of the normal women had severe vitamin D deficiency (less than 20 ng/mL) and 15.2% had mild deficiency (20 to 30 ng/mL) and only 4.8% of women had sufficient vitamin D level (>30 ng/mL) while the proportion was 96.1%, 3.2% and 0.7% respectively for the breast cancer patients. Compared to those with the lowest quartile of plasma 25(OH)D level, women with highest quartile 25(OH)D level showed a significant decreased breast cancer risk (Q4 vs.Q1: OR = 0.10, 95% CI = 0.06-0.15) and
every 1 ng/ml increment of plasma 25(OH)D level led to a 16% lower odds of breast cancer (OR = 0.84, 95% CI = 0.81-0.87; P<0.001).
From the meta-analysis of the observational studies, we found that women with highest quantile of blood 25(OH)D level was associated with a significantly reduced breast cancer risk compared to those with lowest quantile of blood 25(OH)D level for the 11 nested case-control and retrospective studies (pooled OR = 0.86, 95% CI = 0.75-1.00) and
10 case-control studies (7 population based, OR = 0.35, 95% CI = 0.24-0.52;
3 hospital based, OR = 0.08, 95% CI = 0.02-0.33).
These results suggest that vitamin D may have a chemo-preventive effect against breast cancer.
PDF is attached at the bottom of this page
- 3X increased chance of Breast Cancer if recent vitamin D levels were low – Jan 2013
- All items in Cancer - Breast at VitaminDWiki
- Vitamin D and Breast Cancer Incidence and Outcome – Jan 2013
- Compelling evidence – Breast Cancer and vitamin D – Dissertation June 2012
- Not enough women willing to stop taking vitamin D to permit breast cancer clinical trial – June 2012
- 4X less Breast Cancer if have enough vitamin D – Dec 2010
- Triple-negative breast cancer is 3X more frequent if less than 32 ng of vitamin D – March 2012
- Breast tumor 1 inch bigger for each 1 ng decrease in vitamin D – Dec 2011
- Overview Breast Cancer and Vitamin D