ISRN Oncol. 2013;2013:483687. doi: 10.1155/2013/483687. Epub 2013 Feb 26.
Katherine D. Crew 1,2,3
1 Department of Medicine, Division of Hematology/Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
2 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
3 Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer prevention and treatment. Preclinical studies support various antitumor effects of vitamin D in breast cancer. Numerous observational studies have reported an inverse association between vitamin D status, including circulating 25-hydroxyvitamin D (25(OH)D) levels, and breast cancer risk.
The relationship between vitamin D and mammographic density, a strong predictor of breast cancer risk, remains unclear.
Studies analyzing the link between genetic polymorphisms in vitamin D pathway genes and breast cancer incidence and prognosis have yielded inconsistent results.
Vitamin D deficiency among breast cancer patients has been associated with poorer clinical outcomes and increased mortality.
Despite a number of clinical trials of vitamin D supplementation, the efficacy, optimal dosage of vitamin D, and target blood level of 25(OH)D for breast cancer prevention have yet to be determined.
Even with substantial literature on vitamin D and breast cancer, future studies need to focus on gaining a better understanding of the biologic effects of vitamin D in breast tissue.
Despite compelling data from experimental and observational studies, there is still insufficient data from clinical trials to make recommendations for vitamin D supplementation for breast cancer prevention or treatment.
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Wonder when they are going to get around to considering other than monotherapy (only vitamin D), such as Magnesium
- If have breast cancer, should increase vitamin D to more than 30 ng – Jan 2012
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- Quantum dots should deliver active vitamin D directly to inflammatory breast cancer tumors – Feb 2013
- Big Pharma continues to seek a patentable form of vitamin D for Breast Cancer – Nov 2012
- Not enough women willing to stop taking vitamin D to permit breast cancer clinical trial – June 2012
- Low vitamin D associated with dense breasts, which are associated with breast cancer – April 2012
- Hypothesis: increased breast cancer if not enough magnesium – Sept 2010 Low Magnesium is associated with the increase of many diseases
- All items in category Breast Cancer and Vitamin D
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Wide variety of data on vitamin D and breast cancer, but still insufficient clinical data – Feb 2013
- Grassroots Health largest organization focused on Vitamin D and Breast Cancer
Interview of founder in 2011 both Video and transcript
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