ISRN Oncol. 2013;2013:483687. doi: 10.1155/2013/483687. Epub 2013 Feb 26.
Katherine D. Crew 1,2,3
1 Department of Medicine, Division of Hematology/Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
2 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
3 Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer prevention and treatment. Preclinical studies support various antitumor effects of vitamin D in breast cancer. Numerous observational studies have reported an inverse association between vitamin D status, including circulating 25-hydroxyvitamin D (25(OH)D) levels, and breast cancer risk.
The relationship between vitamin D and mammographic density, a strong predictor of breast cancer risk, remains unclear.
Studies analyzing the link between genetic polymorphisms in vitamin D pathway genes and breast cancer incidence and prognosis have yielded inconsistent results.
Vitamin D deficiency among breast cancer patients has been associated with poorer clinical outcomes and increased mortality.
Despite a number of clinical trials of vitamin D supplementation, the efficacy, optimal dosage of vitamin D, and target blood level of 25(OH)D for breast cancer prevention have yet to be determined.
Even with substantial literature on vitamin D and breast cancer, future studies need to focus on gaining a better understanding of the biologic effects of vitamin D in breast tissue.
Despite compelling data from experimental and observational studies, there is still insufficient data from clinical trials to make recommendations for vitamin D supplementation for breast cancer prevention or treatment.
PDF is attached at the bottom of this page
Wonder when they are going to get around to considering other than monotherapy (only vitamin D), such as Magnesium
- If have breast cancer, should increase vitamin D to more than 30 ng – Jan 2012
- Breast Cancer chance decreased 16 percent for every extra ng of vitamin D – Jan 2013
- Quantum dots should deliver active vitamin D directly to inflammatory breast cancer tumors – Feb 2013
- Big Pharma continues to seek a patentable form of vitamin D for Breast Cancer – Nov 2012
- Not enough women willing to stop taking vitamin D to permit breast cancer clinical trial – June 2012
- Low vitamin D associated with dense breasts, which are associated with breast cancer – April 2012
- Hypothesis: increased breast cancer if not enough magnesium – Sept 2010 Low Magnesium is associated with the increase of many diseases
- All items in category Breast Cancer and Vitamin D
- Overview Breast Cancer and Vitamin D
Wide variety of data on vitamin D and breast cancer, but still insufficient clinical data – Feb 2013
- Grassroots Health largest organization focused on Vitamin D and Breast Cancer
Interview of founder in 2011 both Video and transcript
11382 visitors, last modified 08 Jul, 2013,This page is in the following categories (# of items in each category)