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Wide variety of data on vitamin D and breast cancer, but still insufficient clinical data – Feb 2013

Vitamin d: are we ready to supplement for breast cancer prevention and treatment?

ISRN Oncol. 2013;2013:483687. doi: 10.1155/2013/483687. Epub 2013 Feb 26.
Katherine D. Crew 1,2,3
1 Department of Medicine, Division of Hematology/Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
2 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
3 Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA

Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer prevention and treatment. Preclinical studies support various antitumor effects of vitamin D in breast cancer. Numerous observational studies have reported an inverse association between vitamin D status, including circulating 25-hydroxyvitamin D (25(OH)D) levels, and breast cancer risk.
The relationship between vitamin D and mammographic density, a strong predictor of breast cancer risk, remains unclear.
Studies analyzing the link between genetic polymorphisms in vitamin D pathway genes and breast cancer incidence and prognosis have yielded inconsistent results.
Vitamin D deficiency among breast cancer patients has been associated with poorer clinical outcomes and increased mortality.
Despite a number of clinical trials of vitamin D supplementation, the efficacy, optimal dosage of vitamin D, and target blood level of 25(OH)D for breast cancer prevention have yet to be determined.
Even with substantial literature on vitamin D and breast cancer, future studies need to focus on gaining a better understanding of the biologic effects of vitamin D in breast tissue.

Despite compelling data from experimental and observational studies, there is still insufficient data from clinical trials to make recommendations for vitamin D supplementation for breast cancer prevention or treatment.

PMID: 23533810
PDF is attached at the bottom of this page

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Wonder when they are going to get around to considering other than monotherapy (only vitamin D), such as Magnesium

See also VitaminDWiki

See also web

Attached files

ID Name Comment Uploaded Size Downloads
2265 Breast Cancer ready.pdf PDF admin 29 Mar, 2013 20:28 913.98 Kb 781
2264 BC T2.jpg admin 29 Mar, 2013 20:24 61.86 Kb 986
2263 BC T1.jpg admin 29 Mar, 2013 20:23 85.84 Kb 956
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