Vitamin D3 Supplementation and Antibiotic Consumption - Results from a Prospective, Observational Study at an Immune-Deficiency Unit in Sweden.
PLoS One. 2016 Sep 22;11(9):e0163451. doi: 10.1371/journal.pone.0163451.
Norlin AC1,2, Hansen S1, Wahren-Borgström E1, Granert C1, Björkhem-Bergman L3, Bergman P3.
1 Infectious Disease Clinic, Karolinska University Hospital, SE-141 86 Stockholm, Sweden.
2 Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet, 141 86, Stockholm, Sweden.
3 Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden.
Number not using antibiotics increased by 80% during the 12 months after start of vitamin D
They should have ignored results of first ~3 months, when the levels had not yet gotten to a good range
- Antibiotic use cut in half by elderly (over 70) after monthly 60,000 IU of vitamin D – RCT Dec 2013
- Huge increases in health problems – risk factors include Vitamin D, Antibiotics, and Roundup
- Antibiotics and Vitamin D are associated with many of the same diseases
- Antibiotics, probiotics category listing has
81 items along with related searches
Probably: Increased Vitamin D ==> fewer infections ==> less need for antibiotics
Vitamin D supplementation has been proposed to improve clinical symptoms during respiratory tract infections (RTIs), but results from randomized, placebo-controlled trials (RCT) are inconclusive. Previously, we performed an RCT in patients with various immune-disorders and observed that supplementation with 4000 IU vitamin D/day during 12 months significantly reduced antibiotic consumption and RTIs. This formed the basis for new guidelines at our unit; i.e. patients with insufficient levels of 25-hydroxyvitamin D (=75 nmol/L) are now offered vitamin D supplementation. The aim of this prospective follow-up study was to evaluate the outcome of these new recommendations with regard to antibiotic consumption in our unit.
277 patients with insufficiency were supplemented with vitamin D3, 1500-1600 IU/day for 12 months. Each patient was its own control and data on antibiotic consumption was monitored 12 months before and 12 months after initiation of vitamin D3 supplementation.
Vitamin D3 supplementation resulted in a significantly reduced antibiotic consumption, from 20 to 15 days/patient (p<0.05).
The number of antibiotic-free patients increased from 52 to 81 after vitamin D3 supplementation; OR 1.79; 95% CI 1.20-2.66 (p<0.01).
The number of antibiotic-prescriptions decreased significantly, a finding that mainly was attributed to a reduction of respiratory tract antibiotics (p<0.05). Subgroup analysis showed that only patients without immunoglobulin substitution (n = 135) had a significant effect of vitamin D supplementation.
Vitamin D3 supplementation of 1600 IE /day is safe to use in immunodeficient patients with 25-OHD levels less than 75 nmol/L and significantly reduced the antibiotic consumption in patients without immunoglobulin substitution.Antibiotic use decreased after supplementing with 1500 IU of Vitamin D – Sept 2016
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