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Antibiotic use decreased after supplementing with 1500 IU of Vitamin D – Sept 2016

Vitamin D3 Supplementation and Antibiotic Consumption - Results from a Prospective, Observational Study at an Immune-Deficiency Unit in Sweden.

PLoS One. 2016 Sep 22;11(9):e0163451. doi: 10.1371/journal.pone.0163451.
Norlin AC1,2, Hansen S1, Wahren-Borgström E1, Granert C1, Björkhem-Bergman L3, Bergman P3.
1 Infectious Disease Clinic, Karolinska University Hospital, SE-141 86 Stockholm, Sweden.
2 Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet, 141 86, Stockholm, Sweden.
3 Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden.

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Number not using antibiotics increased by 80% during the 12 months after start of vitamin D
They should have ignored results of first ~3 months, when the levels had not yet gotten to a good range

Probably: Increased Vitamin D ==> fewer infections ==> less need for antibiotics

paper was cited 23 times as of June 2021

  • Respiratory Tract Infections and Antibiotic Resistance: A Protective Role for Vitamin D? https://doi.org/10.3389/fnut.2021.652469 March 2021 FREE PDF
  • Effect of monthly vitamin D supplementation on antibiotic prescribing in older adults: a post hoc analysis of a randomized controlled trial - March 2021
  • Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia (Review) - Cochrane July 2018

 Download the PDF from VitaminDWiki

Vitamin D supplementation has been proposed to improve clinical symptoms during respiratory tract infections (RTIs), but results from randomized, placebo-controlled trials (RCT) are inconclusive. Previously, we performed an RCT in patients with various immune-disorders and observed that supplementation with 4000 IU vitamin D/day during 12 months significantly reduced antibiotic consumption and RTIs. This formed the basis for new guidelines at our unit; i.e. patients with insufficient levels of 25-hydroxyvitamin D (=75 nmol/L) are now offered vitamin D supplementation. The aim of this prospective follow-up study was to evaluate the outcome of these new recommendations with regard to antibiotic consumption in our unit.

277 patients with insufficiency were supplemented with vitamin D3, 1500-1600 IU/day for 12 months. Each patient was its own control and data on antibiotic consumption was monitored 12 months before and 12 months after initiation of vitamin D3 supplementation.

Vitamin D3 supplementation resulted in a significantly reduced antibiotic consumption, from 20 to 15 days/patient (p<0.05).
The number of antibiotic-free patients increased from 52 to 81 after vitamin D3 supplementation; OR 1.79; 95% CI 1.20-2.66 (p<0.01).
The number of antibiotic-prescriptions decreased significantly, a finding that mainly was attributed to a reduction of respiratory tract antibiotics (p<0.05). Subgroup analysis showed that only patients without immunoglobulin substitution (n = 135) had a significant effect of vitamin D supplementation.

Vitamin D3 supplementation of 1600 IE /day is safe to use in immunodeficient patients with 25-OHD levels less than 75 nmol/L and significantly reduced the antibiotic consumption in patients without immunoglobulin substitution.

Attached files

ID Name Comment Uploaded Size Downloads
15788 .childhood pneumonia antibiotics Vit D Cochraine.pdf admin 23 Jun, 2021 532.18 Kb 323
15062 Antibiotics and vitamin D.jpg admin 18 Feb, 2021 44.93 Kb 363
7099 Antibiotics PLOS.PDF admin 23 Sep, 2016 1.69 Mb 978