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Warts removed by vitamin D injection - many studies

Vitamin D injection cured a variety of warts on skin - 2017 A

Intralesional Vitamin D3 Injection in the Treatment of Recalcitrant Warts: A Novel Proposition.
J Cutan Med Surg. 2017 Apr 1:1203475417704180. doi: 10.1177/1203475417704180.
Raghukumar S1, Ravikumar BC1, Vinay KN1, Suresh MR1, Aggarwal A1, Yashovardhana DP1.
1 Department of Dermatology, Hassan Institute of Medical Sciences, Hassan, Karnataka state, India.

VitaminDWiki Summary

VitaminDwiki suspects that topical Vitamin D will also treat warts.
Wife has just started topical vitamin D oil applied daily to a 20-year wart on her finger.
   Gave up after a few days - too hard to keep the liquid on the tip of her finger
I suggested that she apply the liquid to band-aid gauze, but she did not try
She also applied Vitamin D to a mole on her arm, which quickly went away

Verruca vulgaris (viral warts) is a fairly common condition with a plethora of treatment options having variable success rates. Recalcitrant warts are refractory to treatment with often disappointing response and high recurrence rates. Lately, treatment with intralesional injections has gained momentum due to its effectiveness in clearing warts by stimulating the cell-mediated immunity. Vitamin D, when applied topically, regulates epidermal cell proliferation and is involved in the formation of antimicrobial peptides. We have attempted to use vitamin D3 to exploit its reported action as an immunotherapeutic molecule in addition to its topical effects. To our knowledge, there are no reports of intralesional vitamin D3 injections used in the treatment of extragenital recalcitrant warts.

Sixty-four patients with recalcitrant warts of varying sizes and duration were included in the study. About 0.2- to 0.5-mL vitamin D3 solution (600,000 IU, 15 mg/mL) was injected to the base of the wart. A maximum of 5 warts were injected per session at 3-week intervals until resolution or for a maximum of 4 treatments. Patients were followed up for 6 months after the last injection to detect any recurrence.

Sixty patients completed the study. Complete response was seen in 54 of 60 (90%), partial response in 4 of 60 (6.66%), and no response in 2 of 60 (3.33%). The average number of injections required to achieve a complete resolution was 3.66. Complete resolution of distant warts was noticed in all patients.

Intralesional vitamin D3 is a safe, effective, and an inexpensive treatment option for recalcitrant warts.

PMID: 28384048 DOI: 10.1177/1203475417704180

Vitamin D injection cured a variety of warts on skin - 2017 B

Safety and efficacy of intralesional vitamin D3 in cutaneous warts: An open uncontrolled trial
J Cutan Aesthet Surg 2017;10:90-4 Year : 2017 | Volume : 10 | Issue : 2 | Page : 90-94
Manjunath Kavya, Basavapura Madegowda Shashikumar, Muddanahalli Rajegowda Harish, Bhadbhade P Shweta
Department of Skin and STD, Mandya Institute of Medical Sciences, Mandya, Karnataka, India
Two images in study via Google Images

Image Image

Background: Cutaneous warts are treated primarily with destructive methods such as cryotherapy or electrocautery. These modalities of treatment are time-consuming and may be associated with scarring in multiple warts. Immunotherapy is emerging as a new modality of treatment which acts on enhancing cell-mediated immunity against human papillomavirus for clearance of both treated and distant warts.

Aims: This study aims to evaluate the safety and efficacy of intralesional Vitamin D3 for the treatment of cutaneous warts. Materials and Methods: Patients with multiple warts were selected for immunotherapy. Vitamin D3 (0.2 ml, 15 mg/ml) was injected to the base of warts after injecting with lignocaine (0.2 ml, 20 mg/ml). The injections were repeated 2 weeks apart for a maximum of 4 sessions or until complete clearance, whichever was earlier. A maximum of 2 warts were treated per session and patients were followed up for 6 months after the last injection.

Results: Forty-two patients with multiple warts were recruited for the study who completed the 6-month follow-up period and were available for analysis. Of these, 23 had palmoplantar warts, 18 had verruca vulgaris and 1 patient had filiform wart. In total, 33 of 42 patients (78.57%) showed complete response, 6 patients (14.28%) showed moderate response and three patients (7.14%) showed mild response. Recurrence was observed in one patient with the palmoplantar wart. No serious adverse effects were reported. Limitations: Lack of control group was the main drawback in our study.

Conclusion: Intralesional Vitamin D3 is safe and effective for treatment of multiple cutaneous warts.

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Warts eliminated in 80 percent of those getting vitamin D injection – Aug 2015

67% of warts cleared by Vitamin D injections - Jan 2020

Comparative clinical study of the efficacy of intralesional MMR vaccine vs intralesional vitamin D injection in treatment of warts
Journal of Cosmetic Dermatology https://doi.org/10.1111/jocd.13272
Dalia R. Shaldoum MBBCh Ghada F. R. Hassan MD Eman H. El Maadawy MD Gamal M. El‐Maghraby MD

Background: Many therapeutic modalities were reported for the treatment of warts; however, no single treatment is completely effective.

Objective: To evaluate the efficacy of intralesional injection of MMR vaccine vs vitamin D in treatment of warts.

Patients and Methods
A total of 60 patients were included in the study divided into two groups. Group A received intralesional MMR vaccine into largest wart, and group B received intralesional vitamin D3 into each lesion with maximum of five warts treated in one session. A maximum of six sessions was done every 3 weeks in both groups. Follow‐up was done for 6 months for any recurrence.

In group A: complete response in 80%, partial response in 6.67%, minimal response in 6.67%, and no response in 6.67% of patients. About 60% of patients with multiple warts showed complete clearance of distant untreated warts.
In group B: complete response in 66.7%, partial response in 6.67%, minimal response in 20%, and no response in 6.67% of patients.
There was no significant difference between both groups. No recurrence was observed in both groups in the follow‐up period.

Immunotherapy by both intralesional MMR vaccine and vitamin D3 is simple, well‐tolerated, effective, and cost‐benefit modalities for the treatment of warts.

Intralesional Vitamin D3 treats of Cutaneous Warts- 2021

Role of Intralesional Vitamin D3 in the Treatment of Cutaneous Warts
Year : 2021 | Volume : 14 | Issue : 4 | Page : 404-408
Insha Latif1, Javeed Sultan2, Aaqib Aslam2, Iffat Hassan2, Reeta Devi2
1 Medical Officer (Dermatologist), District Hospital Ganderbal, Kashmir, J&K, India
2 Post Graduate Department of Dermatology, Venereology and Leprosy, Government Medical College (GMC), Srinagar, Jammu and Kashmir, India

Background: Cutaneous warts are common benign skin lesions caused by human papillomavirus. Various treatment options are available for these but immunotherapy is becoming more and more popular over the past few years. It stimulates cell-mediated immunity causing clearance of warts.

Aims and Objectives: The aim is to determine the role of intralesional vitamin D3 in the treatment of warts. Materials and Methods: Consecutive patients with verruca vulgaris attending OPD were included. Around two to three warts were injected first with 0.2 mL of lignocaine (20 mg/mL). After a few minutes, the same warts were injected with 0.2 mL (4 U) of vitamin D3 (15 mg/mL). The injections were given2 weeks apart for a maximum of six sessions, and the patient was followed up 3 months after the last injection.

Results: A total of 41 patients of cutaneous warts completed the study.

  • Complete clearance was seen in 27 (65.85%) patients,
  • partial response was seen in 11 (26.83%) patients, and three patients
  • (7.32%) showed no response at all.

The mean number of injections required for complete response was four. Recurrence was seen in two patients (4.88%) and one patient had keloid formation at the sight of injection.
Limitation: This is a small sample sized study and lacks a control group.

Conclusion: Intralesional vitamin D3 is an effective treatment option for common warts.
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Created by admin. Last Modification: Monday March 14, 2022 18:57:50 GMT-0000 by admin. (Version 22)

Attached files

ID Name Comment Uploaded Size Downloads
17233 Warts 2021.pdf PDF 2021 admin 14 Mar, 2022 18:52 2.46 Mb 14
9996 Wart B.pdf admin 22 Jun, 2018 13:51 816.00 Kb 627
9995 Warts B2.jpg admin 22 Jun, 2018 13:36 22.16 Kb 5216
9994 Warts B1.jpg admin 22 Jun, 2018 13:36 27.35 Kb 6042
7896 HPV April 2017.pdf PDF 2017 admin 07 Apr, 2017 15:32 351.48 Kb 920
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