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Vitamin D may be proven to help bone grafting in many ways – April 2021

Possible Roles of Vitamin D in Bone Grafting

Cureus. 2021 Apr 26;13(4):e14688. doi: 10.7759/cureus.14688.
Georgios Markopoulos 1, Panagiotis Lepetsos 2, Despina N Perrea 3, Dimitrios C Iliopoulos 3, Vasileios S Nikolaou 1


Anticipate to be succesful that they will need to
1) Raise Vitamin D levels BEFORE bone grafting
2) Provide topical vitamin D directly to the graft
3) Provide cofactors needed to build bone (Magnesium, Boron, etc)

Bone - Health category starts with the following

283 items in Bone - Health category
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Bone grafting is one of the most commonly used options to treat large bone defects. Evidence has shown that vitamin D may affect osseointegration, a major component for successful bone grafting. In vitro studies have proved that implants coated with activated vitamin D stimulate bone production and reduce bone resorption around implants. Animal studies have noticed that oral administration of vitamin D may stimulate bone formation as well as strengthen and support the interaction between bone and implants. Vitamin D insufficiency may affect negatively the cortical peri-implant bone formation, suggesting a negative effect in graft incorporation. Few clinical studies have observed that vitamin D administration enhanced graft incorporation and bone formation, while severe vitamin D deficiency is associated with failed implant osseointegration. Even though there are encouraging results of vitamin D supplementation on graft incorporation in animal studies, the use of vitamin D as an adjuvant in bone grafting procedures cannot be fully supported at the moment. However, there is theoretical support in the use of vitamin D after surgery and the use of bone grafts to support the bone structure, relieve pain and increase graft absorption. Further experimental and clinical studies are required to support the administration of vitamin D and its analogues in such cases.

Created by admin. Last Modification: Monday May 31, 2021 21:29:41 GMT-0000 by admin. (Version 2)

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15687 Vitamin D in Bone Grafting.pdf PDF 2021 admin 31 May, 2021 21:29 125.57 Kb 114
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