Vitamin D levels massively changed by CYP3A4 gene (drugs such as Ivermectin and anti-epileptics)

Deactivation of CYP3A4 by drugs such as Ivermectin INCREASE calcitriol and calcidriol (Vitamin D)
Activation of CYP3A4 by drugs such as some anti-epileptics DECREASE calcitriol and calcidriol (Vitamin D)

• Ivermectin raises levels of vitamin D (by decreasing CYP3A4)
• Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022
• Changes in CYP3A4 gene affects Vitamin D, health, reactions to some drugs, etc - June 2022
• Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities,
  targeting CYP3A4*1G allele function. -  PDF
• Interplay between Vitamin D and the Drug Metabolizing Enzyme CYP3A4 - July 2014 -  PDF
  • "For example, daily administration of rifampin (anti-epileptic) to healthy volunteers lowered the plasma concentration of 25OHD3 by 70%"
• CYP3A4 mutation causes vitamin D–dependent rickets type 3 - Feb 2018 -  PDF
• Role of vitamin D receptor in the regulation of CYP3A gene expression - Nov 2019 -  PDF
• VDR regulates CYP3A4 2002  PDF

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See also Ivermectin and COVID-19 - many studies

Genetics category listing contains the following

332 articles in the Genetics category

see also

• Vitamin D Receptor has 513 items
• Vitamin D Binding Protein = GC has 176 items
• CYP27B1 has 60 items
• CYP24A1 in title of 34+ items
• CYP2R1 25+ items
• Calcidiol has 46 items
• Calcitriol has 56 items
• Topical Vitamin D
• Nanoemulsion Vitamin D may be a substantially better form
• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
• CYP3A4 (7 as of Dec 2022)
• Getting Vitamin D into your body
• 

Vitamin D blood test misses a lot

• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
• Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
• A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
  • However, test results would vary in each tissue due to multiple genes
• Good clues that Vitamin D is being restricted from getting to the cells
  1) A vitamin D-related health problem runs in the family

    especially if it is one of 51+ diseases related to Vitamin D Receptor

+2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase) +3) DNA and VDR tests - 120 to 200 dollars $100 to $250 +4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)

   Genes are good, have enough Magnesium, etc.

+4) Back Pain

   probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc

• The founder of VitaminDWiki took action with clues #3&4

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Web

• CYP3A4 Wikipedia
  • CYP3A4metabolizes about half of all drugs: examples include:acetaminophen, codeine, ciclosporin (cyclosporin), diazepam, and erythromycin
  • grapefruit juice ... is a potent inhibitor of CYP3A4, which can affect the metabolism of a variety of drugs, increasing their bioavailability.