Deactivation of CYP3A4 by drugs such as Ivermectin INCREASE calcitriol and calcidriol (Vitamin D)
Activation of CYP3A4 by drugs (anti-epileptics. Valium etc DECREASE calcitriol and calcidriol (Vitamin D)
- Ivermectin raises levels of vitamin D (by decreasing CYP3A4)
- Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022
- Changes in CYP3A4 gene affects Vitamin D, health, reactions to some drugs, etc - June 2022
- Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities,
targeting CYP3A4*1G allele function. - PDF - Interplay between Vitamin D and the Drug Metabolizing Enzyme CYP3A4 - July 2014 - PDF
- "For example, daily administration of rifampin (anti-epileptic) to healthy volunteers lowered the plasma concentration of 25OHD3 by 70%"
- CYP3A4 mutation causes vitamin D–dependent rickets type 3 - Feb 2018 - PDF
- Role of vitamin D receptor in the regulation of CYP3A gene expression - Nov 2019 - PDF
- VDR regulates CYP3A4 2002 PDF
- Valium, Xanax change activation of CYP3A4, which decreases calcitriol and calcidriol Perplexity AI PDF July 2025
- Large doses of flavanoids might reduce activation of CYP3A4 (increasing Vitamin D getting to cells) - 2024 FREE PDF
Genetics chart
Web
- CYP3A4 Wikipedia
- CYP3A4metabolizes about half of all drugs: examples include:acetaminophen, codeine, ciclosporin (cyclosporin), diazepam, and erythromycin
- grapefruit juice ... is a potent inhibitor of CYP3A4, which can affect the metabolism of a variety of drugs, increasing their bioavailability.