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Vitamin D – individual responses to 100,000 IU – March 2017

Impact of a single oral dose of 100,000 IU vitamin D3 on profiles of serum 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in adults with vitamin D insufficiency

Clinical Chemistry and Laboratory Medicine (CCLM) .Online: 2017-03-22 |
DOI: https://doi.org/10.1515/cclm-2016-1129

Blood level Vitamin D - before and 4 weeks after oral dose

https://vitamindwiki.com/tiki-index.php?page_id=8333
52% achieved levels > 30 ng; approximate 20 ng increase - with lots of variability

Active Vitamin D - before and 4 weeks after oral dose

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See also VitaminDWiki

Response to single 20,000 IU
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Reasons for low response to vitamin D ~40 reasons
Overview Loading of vitamin D has the following
Response to a single dose of 100,000 IU starting at 27 ng/ml, half life is about 50 days
see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=1046

People in this study were not obese - obese would have has lower responses
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  • Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study

Large dose of vitamin D (200,000 IU) lasts for about 100 days – Feb 2015

200,000 IU
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 Download the PDF from VitaminDWiki

Background:
We investigate the effect of a high dose of vitamin D3 on circulating concentrations of 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in healthy individuals with self-perceived fatigue and vitamin D insufficiency [25(OH)D3<50 nmol/L].

Methods:
One hundred and seven study participants (age 20–50 years) were randomized to receive a single 100,000 IU dose of vitamin D3 (n=52) or placebo (n=55). Vitamin D metabolite concentrations in serum were measured before, and 4 weeks after, supplementation.

Results:
Overall, 52% of participants receiving vitamin D3 attained a serum 25(OH)D3 level >75 nmol/L. Among individuals who received vitamin D3, there were significant increases in serum concentrations of 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 at 4 weeks; however, inter-individual variability in these changes was substantial. Positive correlations between serum 25(OH)D3 and 24,25(OH)2D3 and 3-epi-25(OH)D3, and a significant negative correlation between serum 1,25(OH)2D3 and 3-epi-25(OH)D3, were found 4 weeks after supplementation. The 24,25(OH)2D3/25(OH)D3 and 24,25(OH)2D3/1,25(OH)2D3 ratios were significantly increased, compared with baseline, in participants receiving vitamin D3. Baseline 25(OH)D3 concentration was the only factor predictive of the change in 25(OH)D3 after supplementation.

Conclusions:
Administration of a single high dose of vitamin D3 leads to a significant increase in concentrations of 25(OH)D3, 24,25(OH)2D3, 3-epi-25(OH)D3 and 1,25(OH)2D3; induction of the catabolic pathway predominates over the production of 1,25(OH)2D3. Due to the high inter-individual variation in the 25(OH)D3 response to supplementation, any given dose of vitamin D is unlikely to achieve optimal vitamin D status in all treated individuals

Attached files

ID Name Comment Uploaded Size Downloads
7873 100,000 1,25.jpg admin 23 Mar, 2017 28.80 Kb 1215
7872 100,000.pdf admin 23 Mar, 2017 1.12 Mb 953