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Staph infections with eczema reduced with 2,000 IU of vitamin D – RCT Oct 2015

The Effects of Oral Vitamin D Supplement on Atopic Dermatitis: A Clinical Trial with Staphylococcus aureus Colonization Determination.

J Med Assoc Thai. 2015 Oct;98 Suppl 9:S23-30.
Udompataikul M, Huajai S, Chalermchai T, Taweechotipatr M, Kamanamool N.

VitaminDWiki Summary

Used 2,000 IU daily for 4 weeks
Even far better benefits expected if had used any/all of the following

  1. Loading dose – Consume 350,000 IU of vitamin D in a week
  2. Higher daily dose – say 4,000 IU
  3. Longer dosing period – say 8 or 12 weeks

See also VitaminDWiki

BACKGROUND:
An increase in Staphylococcus aureus skin colonization in atopic dermatitis patients resulted from the reduction of cathelicidin production in these patients. Recently, an in vivo study demonstrated that vitamin D could stimulate cathelicidin production. Oral supplements of vitamin D might be beneficial in atopic dermatitis.

OBJECTIVE:
To determine the effects of oral vitamin D supplements on clinical impact including Staphylococcus aureus skin colonization evaluation in atopic dermatitis patients.

MATERIAL AND METHOD:
Twenty-four atopic dermatitis patients were included in this double-blind, placebo-controlled study. They were randomly assigned into 2 groups for oral 2,000 IUs/day of vitamin D, supplement and placebo. The lesional swab culture for S. aureus was done at week 0, 2 and 4. Clinical outcomes were assessed by SCORAD score, mexameter for erythema index and konometer for conductance were done at week 0, 2 and 4. Serum vitamin D levels were also determined at week 0 and 4.

RESULTS:
Twenty patients completed the protocol. S. aureus skin colonization, SCORAD score and erythema index were significantly reduced from baseline to week 4 for vitamin D treated group comparing with placebo (p = 0.022, 0.028 and 0.014, respectively). There was an inverse correlation between serum vitamin D levels with S. aureus skin colonization and SCORAD score (r = -1.0, p < 0.001).

CONCLUSION:
Oral vitamin D supplement could reduce skin colonization of S. aureus and demonstrated the clinical improvement of patients with atopic dermatitis.

PMID: 26817206

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